Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention
In the continued battle against one of the oldest enemies known to mankind, <i>Mycobacterium tuberculosis (MTB)</i>, the emergence of drug resistance to antituberculosis drugs among children poses multiple challenges for early detection and treatment. Molecular diagnostics and newer drug...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/12/11/1372 |
| _version_ | 1827639097788727296 |
|---|---|
| author | Dhanya Dharmapalan Sushant Satish Mane |
| author_facet | Dhanya Dharmapalan Sushant Satish Mane |
| author_sort | Dhanya Dharmapalan |
| collection | DOAJ |
| description | In the continued battle against one of the oldest enemies known to mankind, <i>Mycobacterium tuberculosis (MTB)</i>, the emergence of drug resistance to antituberculosis drugs among children poses multiple challenges for early detection and treatment. Molecular diagnostics and newer drugs like bedaquiline and delamanid have strengthened the armamentarium and helped design convenient, safe, and child-friendly therapeutic regimens against drug-resistant tuberculosis (TB). Preventive strategies like treatment of TB infection among children living in close contact with patients with drug-resistant TB and effective vaccines against TB are currently in the investigative stages of development and implementation. In addition to the implementation of recent novel diagnostics and treatment modalities, effective psychosocial and nutritional support, as well as dedicated monitoring for compliance and adverse effects, are crucial determinants for successful treatment outcomes in these children. |
| first_indexed | 2024-03-09T16:32:55Z |
| format | Article |
| id | doaj.art-fde9a42608d24faf828c3e2abc5884fa |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T16:32:55Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-fde9a42608d24faf828c3e2abc5884fa2023-11-24T14:59:58ZengMDPI AGPathogens2076-08172023-11-011211137210.3390/pathogens12111372Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and PreventionDhanya Dharmapalan0Sushant Satish Mane1Apollo Hospitals, Navi Mumbai 400614, IndiaSir JJ Group of Hospitals, Grant Govt. Medical College, Mumbai 400008, IndiaIn the continued battle against one of the oldest enemies known to mankind, <i>Mycobacterium tuberculosis (MTB)</i>, the emergence of drug resistance to antituberculosis drugs among children poses multiple challenges for early detection and treatment. Molecular diagnostics and newer drugs like bedaquiline and delamanid have strengthened the armamentarium and helped design convenient, safe, and child-friendly therapeutic regimens against drug-resistant tuberculosis (TB). Preventive strategies like treatment of TB infection among children living in close contact with patients with drug-resistant TB and effective vaccines against TB are currently in the investigative stages of development and implementation. In addition to the implementation of recent novel diagnostics and treatment modalities, effective psychosocial and nutritional support, as well as dedicated monitoring for compliance and adverse effects, are crucial determinants for successful treatment outcomes in these children.https://www.mdpi.com/2076-0817/12/11/1372bedaquiline (BDQ)delamanid (DLM)Xpert MTBtuberculosisTB infectionlatent TB |
| spellingShingle | Dhanya Dharmapalan Sushant Satish Mane Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention Pathogens bedaquiline (BDQ) delamanid (DLM) Xpert MTB tuberculosis TB infection latent TB |
| title | Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention |
| title_full | Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention |
| title_fullStr | Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention |
| title_full_unstemmed | Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention |
| title_short | Pediatric Drug-Resistant Tuberculosis: The Current and Future Prospects for Management and Prevention |
| title_sort | pediatric drug resistant tuberculosis the current and future prospects for management and prevention |
| topic | bedaquiline (BDQ) delamanid (DLM) Xpert MTB tuberculosis TB infection latent TB |
| url | https://www.mdpi.com/2076-0817/12/11/1372 |
| work_keys_str_mv | AT dhanyadharmapalan pediatricdrugresistanttuberculosisthecurrentandfutureprospectsformanagementandprevention AT sushantsatishmane pediatricdrugresistanttuberculosisthecurrentandfutureprospectsformanagementandprevention |