Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-05-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520922416 |
| _version_ | 1819292692748697600 |
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| author | Jiahui Yang Fangli Wu Dan Luo Miaojing Li Xinming Gou Jieying Xi Huachao Zhu |
| author_facet | Jiahui Yang Fangli Wu Dan Luo Miaojing Li Xinming Gou Jieying Xi Huachao Zhu |
| author_sort | Jiahui Yang |
| collection | DOAJ |
| description | A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN. |
| first_indexed | 2024-12-24T03:58:35Z |
| format | Article |
| id | doaj.art-fde9b895a78d4521984626c584169a51 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-24T03:58:35Z |
| publishDate | 2020-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-fde9b895a78d4521984626c584169a512022-12-21T17:16:23ZengSAGE PublishingJournal of International Medical Research1473-23002020-05-014810.1177/0300060520922416Toxic epidermal necrolysis syndrome induced by tigecycline: a case reportJiahui YangFangli WuDan LuoMiaojing LiXinming GouJieying XiHuachao ZhuA 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN.https://doi.org/10.1177/0300060520922416 |
| spellingShingle | Jiahui Yang Fangli Wu Dan Luo Miaojing Li Xinming Gou Jieying Xi Huachao Zhu Toxic epidermal necrolysis syndrome induced by tigecycline: a case report Journal of International Medical Research |
| title | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
| title_full | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
| title_fullStr | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
| title_full_unstemmed | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
| title_short | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
| title_sort | toxic epidermal necrolysis syndrome induced by tigecycline a case report |
| url | https://doi.org/10.1177/0300060520922416 |
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