Transcriptional regulation of Notch1 by nuclear factor-κB during T cell activation

Abstract Notch1 plays important roles in T cell development and is highly expressed in activated CD4+ T cells. However, the underlying mechanism of Notch1 transcription in T cells has not been fully characterized. Therefore, we aimed to determine how Notch1 expression is regulated during the activat...

Descrizione completa

Dettagli Bibliografici
Autori principali: Jeong-Ryul Hwang, Donghwan Kim, Jung-Ah Kang, Sang-Heon Park, Sung-Gyoo Park
Natura: Articolo
Lingua:English
Pubblicazione: Nature Portfolio 2023-01-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-022-26674-1