Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia
Recently, there has been an increased focus on the influences of mitochondrial dysfunction on various pathologies. Mitochondria are major intracellular organelles with a variety of critical roles, such as adenosine triphosphate production, metabolic modulation, generation of reactive oxygen species,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.565023/full |
| _version_ | 1818292103071924224 |
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| author | Koji Takemura Hiroshi Nishi Reiko Inagi |
| author_facet | Koji Takemura Hiroshi Nishi Reiko Inagi |
| author_sort | Koji Takemura |
| collection | DOAJ |
| description | Recently, there has been an increased focus on the influences of mitochondrial dysfunction on various pathologies. Mitochondria are major intracellular organelles with a variety of critical roles, such as adenosine triphosphate production, metabolic modulation, generation of reactive oxygen species, maintenance of intracellular calcium homeostasis, and the regulation of apoptosis. Moreover, mitochondria are attracting attention as a therapeutic target in several diseases. Additionally, a lot of existing agents have been found to have pharmacological effects on mitochondria. This review provides an overview of the mitochondrial change in the kidney and skeletal muscle, which is often complicated with sarcopenia and chronic kidney disease (CKD). Furthermore, the pharmacological effects of therapeutics for CKD on mitochondria are explored. |
| first_indexed | 2024-12-13T02:54:38Z |
| format | Article |
| id | doaj.art-fded44bbf2d340c18ba0d86d4f9f94b7 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-13T02:54:38Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-fded44bbf2d340c18ba0d86d4f9f94b72022-12-22T00:01:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.565023565023Mitochondrial Dysfunction in Kidney Disease and Uremic SarcopeniaKoji Takemura0Hiroshi Nishi1Reiko Inagi2Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDivision of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanDivision of CKD Pathophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo, JapanRecently, there has been an increased focus on the influences of mitochondrial dysfunction on various pathologies. Mitochondria are major intracellular organelles with a variety of critical roles, such as adenosine triphosphate production, metabolic modulation, generation of reactive oxygen species, maintenance of intracellular calcium homeostasis, and the regulation of apoptosis. Moreover, mitochondria are attracting attention as a therapeutic target in several diseases. Additionally, a lot of existing agents have been found to have pharmacological effects on mitochondria. This review provides an overview of the mitochondrial change in the kidney and skeletal muscle, which is often complicated with sarcopenia and chronic kidney disease (CKD). Furthermore, the pharmacological effects of therapeutics for CKD on mitochondria are explored.https://www.frontiersin.org/article/10.3389/fphys.2020.565023/fullmitochondriaCKD - chronic kidney diseasesarcopeniakidneyskeletal muscle |
| spellingShingle | Koji Takemura Hiroshi Nishi Reiko Inagi Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia Frontiers in Physiology mitochondria CKD - chronic kidney disease sarcopenia kidney skeletal muscle |
| title | Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia |
| title_full | Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia |
| title_fullStr | Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia |
| title_full_unstemmed | Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia |
| title_short | Mitochondrial Dysfunction in Kidney Disease and Uremic Sarcopenia |
| title_sort | mitochondrial dysfunction in kidney disease and uremic sarcopenia |
| topic | mitochondria CKD - chronic kidney disease sarcopenia kidney skeletal muscle |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.565023/full |
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