Effects of aspirin on renal cortical and medullary tissues in rat embryos
Background: Aspirin is the drug of the century, and is a multifunctional drug and one of the most prescribed drugs in the world. Aspirin is a safe drug at low doses but also it has life-threatening side effects when administered at high doses. This study investi-gates the effects of aspirin on renal...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2013-12-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5144&slc_lang=en&sid=1 |
| _version_ | 1811296172425347072 |
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| author | Seyed Homayoon Sadraie Fatemeh Rezaei Mahnaz Azarnia Gholamreza Kaka Soheila Jahani Zahra Shabani |
| author_facet | Seyed Homayoon Sadraie Fatemeh Rezaei Mahnaz Azarnia Gholamreza Kaka Soheila Jahani Zahra Shabani |
| author_sort | Seyed Homayoon Sadraie |
| collection | DOAJ |
| description | Background: Aspirin is the drug of the century, and is a multifunctional drug and one of the most prescribed drugs in the world. Aspirin is a safe drug at low doses but also it has life-threatening side effects when administered at high doses. This study investi-gates the effects of aspirin on renal cortical and medullary tissue in rat embryos.Methods: In this study, 30 pregnant female rats were randomly divided into 6 groups. Control group with no intervention, sham group received 2 ml distilled water (as a sol-vent of aspirin) received from days 8 to 20 of pregnancy, and four experimental groups received different doses of 75, 100, 200 and 300 mg/kg of aspirin by gavage. Pregnant rats were sacrificed on the twenty days of pregnancy and the fetuses were removed. Weight of the fetuses and placenta and Crown-Rump length were measured. Fetal kid-neys were fixed in formalin processed, sectioned and stained with Hematoxylin- Eosin. Thickness of renal cortical and medullary tissue by using a Motic hardware and soft-ware system were measured and recorded. A significance level of 0.05 was predeter-mined for all statistical analyses.Results: No apparent fetal anomalies were observed in experimental groups. In addi-tion, no significant differences were shown in the mean of fetal weight, placental weight, mean of Crown-Rump length in experimental groups 75, 200 and 300 mg/kg compared to control and sham groups. Mean fetal and placental weight in experimental group 100 significantly increased compared to control and sham groups. Mean ratio of renal cortex to renal medulla in experimental group 75, 100 and 300 were significantly decreased compared to control and sham groups (respectively P= 0.03, P= 0.013, P= 0.03).Conclusion: It seems that maternal use of aspirin during pregnancy can not cause fetal abnormalities. However, it can cause some changes in renal cortical and medullary tis-sue of rat embryos. |
| first_indexed | 2024-04-13T05:44:30Z |
| format | Article |
| id | doaj.art-fded55ffcba54f3a8ebbf11a335c266d |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-04-13T05:44:30Z |
| publishDate | 2013-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-fded55ffcba54f3a8ebbf11a335c266d2022-12-22T02:59:59ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222013-12-01719562567Effects of aspirin on renal cortical and medullary tissues in rat embryosSeyed Homayoon Sadraie 0Fatemeh Rezaei 1Mahnaz Azarnia 2Gholamreza Kaka 3Soheila Jahani 4Zahra Shabani 5 Neurosciences Research Center, Department of Anatomy, Baqiyatal-lah University of Medical Sciences, Tehran, Iran. Department of Biology, Kharazmy University, Tehran, Iran. Department of Biology, Kharazmy University, Tehran, Iran. Neurosciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Department of Biology, Kharazmy University, Tehran, Iran. Department of Biology, School of Science, Tehran North branch, AZAD Islamic University, Tehran, Iran. Background: Aspirin is the drug of the century, and is a multifunctional drug and one of the most prescribed drugs in the world. Aspirin is a safe drug at low doses but also it has life-threatening side effects when administered at high doses. This study investi-gates the effects of aspirin on renal cortical and medullary tissue in rat embryos.Methods: In this study, 30 pregnant female rats were randomly divided into 6 groups. Control group with no intervention, sham group received 2 ml distilled water (as a sol-vent of aspirin) received from days 8 to 20 of pregnancy, and four experimental groups received different doses of 75, 100, 200 and 300 mg/kg of aspirin by gavage. Pregnant rats were sacrificed on the twenty days of pregnancy and the fetuses were removed. Weight of the fetuses and placenta and Crown-Rump length were measured. Fetal kid-neys were fixed in formalin processed, sectioned and stained with Hematoxylin- Eosin. Thickness of renal cortical and medullary tissue by using a Motic hardware and soft-ware system were measured and recorded. A significance level of 0.05 was predeter-mined for all statistical analyses.Results: No apparent fetal anomalies were observed in experimental groups. In addi-tion, no significant differences were shown in the mean of fetal weight, placental weight, mean of Crown-Rump length in experimental groups 75, 200 and 300 mg/kg compared to control and sham groups. Mean fetal and placental weight in experimental group 100 significantly increased compared to control and sham groups. Mean ratio of renal cortex to renal medulla in experimental group 75, 100 and 300 were significantly decreased compared to control and sham groups (respectively P= 0.03, P= 0.013, P= 0.03).Conclusion: It seems that maternal use of aspirin during pregnancy can not cause fetal abnormalities. However, it can cause some changes in renal cortical and medullary tis-sue of rat embryos.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5144&slc_lang=en&sid=1aspirin fetus kidney rats |
| spellingShingle | Seyed Homayoon Sadraie Fatemeh Rezaei Mahnaz Azarnia Gholamreza Kaka Soheila Jahani Zahra Shabani Effects of aspirin on renal cortical and medullary tissues in rat embryos Tehran University Medical Journal aspirin fetus kidney rats |
| title | Effects of aspirin on renal cortical and medullary tissues in rat embryos |
| title_full | Effects of aspirin on renal cortical and medullary tissues in rat embryos |
| title_fullStr | Effects of aspirin on renal cortical and medullary tissues in rat embryos |
| title_full_unstemmed | Effects of aspirin on renal cortical and medullary tissues in rat embryos |
| title_short | Effects of aspirin on renal cortical and medullary tissues in rat embryos |
| title_sort | effects of aspirin on renal cortical and medullary tissues in rat embryos |
| topic | aspirin fetus kidney rats |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5144&slc_lang=en&sid=1 |
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