Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease
Background: Red cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with microalbuminuria, an indicator of target organ damag...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2017-09-01
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| Series: | Kidney Research and Clinical Practice |
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| Online Access: | https://doi.org/10.23876/j.krcp.2017.36.3.232 |
| _version_ | 1818906265725698048 |
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| author | Young Youl Hyun Hyang Kim Kyu-Beck Lee |
| author_facet | Young Youl Hyun Hyang Kim Kyu-Beck Lee |
| author_sort | Young Youl Hyun |
| collection | DOAJ |
| description | Background: Red cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with microalbuminuria, an indicator of target organ damage. However, the longitudinal association of RDW and development of albuminuria is not known. Methods: We analyzed 83,040 participants without chronic kidney disease (CKD) at baseline who underwent two health check-ups at a 4-year interval during 2005 to 2014. Urine albumin was determined by single urine dipstick semi-quantitative analysis, and incident albuminuria was defined as ≥ 1+ dipstick albumin at the second check-up. We used logistic regression analysis to determine the relationship between RDW and incident albuminuria. Results: Participants were divided into quartiles according to baseline RDW. After 4 years, 982 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.94, 1.05, 1.18, and 1.62% for the 1st through 4th quartiles of RDW, respectively. Multivariate logistic analysis showed that the odds ratios (95% confidence interval) for incident albuminuria compared to those in the 1st quartile were 1.11 (0.92–1.34), 1.26 (1.04–1.52), and 1.88 (1.58–2.24) for the 2nd, 3rd and 4th quartiles, respectively. Conclusion: RDW was associated with development of albuminuria in relatively healthy Korean adults without CKD. Further research is needed to verify the role of RDW in the development of albuminuria and renal injury. |
| first_indexed | 2024-12-19T21:36:29Z |
| format | Article |
| id | doaj.art-fdee0caeb00d4d25a7943ba27bad2fe0 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-19T21:36:29Z |
| publishDate | 2017-09-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-fdee0caeb00d4d25a7943ba27bad2fe02022-12-21T20:04:47ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322017-09-0136323223910.23876/j.krcp.2017.36.3.232j.krcp.2017.36.3.232Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney diseaseYoung Youl Hyun0Hyang Kim1Kyu-Beck Lee2Division of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaDivision of Nephrology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground: Red cell distribution width (RDW) is an emerging marker of inflammation and a predictor of high cardiovascular morbidity and mortality as well as all-cause mortality. A previous cross-sectional study showed that RDW was associated with microalbuminuria, an indicator of target organ damage. However, the longitudinal association of RDW and development of albuminuria is not known. Methods: We analyzed 83,040 participants without chronic kidney disease (CKD) at baseline who underwent two health check-ups at a 4-year interval during 2005 to 2014. Urine albumin was determined by single urine dipstick semi-quantitative analysis, and incident albuminuria was defined as ≥ 1+ dipstick albumin at the second check-up. We used logistic regression analysis to determine the relationship between RDW and incident albuminuria. Results: Participants were divided into quartiles according to baseline RDW. After 4 years, 982 cases of incident albuminuria were observed. The cumulative incidences of albuminuria were 0.94, 1.05, 1.18, and 1.62% for the 1st through 4th quartiles of RDW, respectively. Multivariate logistic analysis showed that the odds ratios (95% confidence interval) for incident albuminuria compared to those in the 1st quartile were 1.11 (0.92–1.34), 1.26 (1.04–1.52), and 1.88 (1.58–2.24) for the 2nd, 3rd and 4th quartiles, respectively. Conclusion: RDW was associated with development of albuminuria in relatively healthy Korean adults without CKD. Further research is needed to verify the role of RDW in the development of albuminuria and renal injury.https://doi.org/10.23876/j.krcp.2017.36.3.232AlbuminuriaChronic kidney diseaseRed cell distribution width |
| spellingShingle | Young Youl Hyun Hyang Kim Kyu-Beck Lee Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease Kidney Research and Clinical Practice Albuminuria Chronic kidney disease Red cell distribution width |
| title | Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease |
| title_full | Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease |
| title_fullStr | Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease |
| title_full_unstemmed | Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease |
| title_short | Red cell distribution width predicts incident dipstick albuminuria in Korean adults without chronic kidney disease |
| title_sort | red cell distribution width predicts incident dipstick albuminuria in korean adults without chronic kidney disease |
| topic | Albuminuria Chronic kidney disease Red cell distribution width |
| url | https://doi.org/10.23876/j.krcp.2017.36.3.232 |
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