Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

The positive transcription elongation factor b (P-TEFb) is a critical coactivator for transcription of most cellular and viral genes, including those of HIV. While P-TEFb is regulated by 7SK snRNA in proliferating cells, P-TEFb is absent due to diminished levels of CycT1 in quiescent and terminally...

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Bibliographic Details
Main Authors: Fang Huang, Trang TT Nguyen, Ignacia Echeverria, Ramachandran Rakesh, Daniele C Cary, Hana Paculova, Andrej Sali, Arthur Weiss, Boris Matija Peterlin, Koh Fujinaga
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
P-TEFb
PKC
PP1
phosphorylation
transcription
anergy
Online Access:https://elifesciences.org/articles/68473

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