A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation
Collided ribosomes are marked by ubiquitination to induce quality control mechanisms. Here, authors show that mammalian disomes form a distinct structural interface, in which uS10 K63-linked polyubiquitination is critical for ribosome dissociation.
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-34097-9 |
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author | Momoko Narita Timo Denk Yoshitaka Matsuo Takato Sugiyama Chisato Kikuguchi Sota Ito Nichika Sato Toru Suzuki Satoshi Hashimoto Iva Machová Petr Tesina Roland Beckmann Toshifumi Inada |
author_facet | Momoko Narita Timo Denk Yoshitaka Matsuo Takato Sugiyama Chisato Kikuguchi Sota Ito Nichika Sato Toru Suzuki Satoshi Hashimoto Iva Machová Petr Tesina Roland Beckmann Toshifumi Inada |
author_sort | Momoko Narita |
collection | DOAJ |
description | Collided ribosomes are marked by ubiquitination to induce quality control mechanisms. Here, authors show that mammalian disomes form a distinct structural interface, in which uS10 K63-linked polyubiquitination is critical for ribosome dissociation. |
first_indexed | 2024-04-13T17:20:03Z |
format | Article |
id | doaj.art-fdef5afc077647cc8ee2226266299005 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-13T17:20:03Z |
publishDate | 2022-10-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-fdef5afc077647cc8ee22262662990052022-12-22T02:38:02ZengNature PortfolioNature Communications2041-17232022-10-0113111610.1038/s41467-022-34097-9A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociationMomoko Narita0Timo Denk1Yoshitaka Matsuo2Takato Sugiyama3Chisato Kikuguchi4Sota Ito5Nichika Sato6Toru Suzuki7Satoshi Hashimoto8Iva Machová9Petr Tesina10Roland Beckmann11Toshifumi Inada12Division of RNA and gene regulation, Institute of Medical Science, The University of TokyoGene Center and Department of Biochemistry, University of MunichDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoGraduate School of Pharmaceutical Sciences, Tohoku UniversityDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoGraduate School of Pharmaceutical Sciences, Tohoku UniversityBiomedical Centre, Faculty of Medicine in Pilsen, Charles University in PragueGene Center and Department of Biochemistry, University of MunichGene Center and Department of Biochemistry, University of MunichDivision of RNA and gene regulation, Institute of Medical Science, The University of TokyoCollided ribosomes are marked by ubiquitination to induce quality control mechanisms. Here, authors show that mammalian disomes form a distinct structural interface, in which uS10 K63-linked polyubiquitination is critical for ribosome dissociation.https://doi.org/10.1038/s41467-022-34097-9 |
spellingShingle | Momoko Narita Timo Denk Yoshitaka Matsuo Takato Sugiyama Chisato Kikuguchi Sota Ito Nichika Sato Toru Suzuki Satoshi Hashimoto Iva Machová Petr Tesina Roland Beckmann Toshifumi Inada A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation Nature Communications |
title | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation |
title_full | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation |
title_fullStr | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation |
title_full_unstemmed | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation |
title_short | A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation |
title_sort | distinct mammalian disome collision interface harbors k63 linked polyubiquitination of us10 to trigger hrqt mediated subunit dissociation |
url | https://doi.org/10.1038/s41467-022-34097-9 |
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