Regulation of GM Organisms for Invasive Species Control
Invasive species can cause significant harm to the environment, agriculture, and human health, but there are often very limited tools available to control their populations. Gene drives (GD) have been proposed as a new tool which could be used to control or eliminate such species. Here, GD describes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2019.00454/full |
| _version_ | 1819077830042976256 |
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| author | Heidi J. Mitchell Detlef Bartsch |
| author_facet | Heidi J. Mitchell Detlef Bartsch |
| author_sort | Heidi J. Mitchell |
| collection | DOAJ |
| description | Invasive species can cause significant harm to the environment, agriculture, and human health, but there are often very limited tools available to control their populations. Gene drives (GD) have been proposed as a new tool which could be used to control or eliminate such species. Here, GD describes a variety of molecular biology applications which all enable the introduction of genetic elements at a higher than expected frequency. These elements can change the genotypes in target populations rapidly with consequences either for (intrinsic) fitness or host-parasite interaction, or both. Beneficial applications are foreseen for human and animal health, agriculture, or nature conservation. This rapidly developing technology is likely to have major impacts in the fight against various diseases, pests, and invasive species. The majority of GD applications involve genetic engineering and novel traits. Therefore, applicants and GMO regulators need to interact to achieve the benefits in innovation while cautiously avoiding unacceptable risks. The release into the environment may include transboundary movement and replacement of target populations, with potential impact on human/animal health and the environment. This article summarizes knowledge-based discussions to identify information gaps and analyzes scenarios for responsible introduction of GD organisms into the environment. It aims to connect the latest scientific developments with regulatory approaches and decision-making. |
| first_indexed | 2024-12-21T19:03:26Z |
| format | Article |
| id | doaj.art-fdef66825d64421cab169c611977d869 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-21T19:03:26Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-fdef66825d64421cab169c611977d8692022-12-21T18:53:25ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-01-01710.3389/fbioe.2019.00454488554Regulation of GM Organisms for Invasive Species ControlHeidi J. Mitchell0Detlef Bartsch1Office of the Gene Technology Regulator, Australian Government Department of Health, Canberra, ACT, AustraliaFederal Office of Consumer Protection and Food Safety, Bundesamt für Verbraucherschutz und Lebensmittelsicherheit, Berlin, GermanyInvasive species can cause significant harm to the environment, agriculture, and human health, but there are often very limited tools available to control their populations. Gene drives (GD) have been proposed as a new tool which could be used to control or eliminate such species. Here, GD describes a variety of molecular biology applications which all enable the introduction of genetic elements at a higher than expected frequency. These elements can change the genotypes in target populations rapidly with consequences either for (intrinsic) fitness or host-parasite interaction, or both. Beneficial applications are foreseen for human and animal health, agriculture, or nature conservation. This rapidly developing technology is likely to have major impacts in the fight against various diseases, pests, and invasive species. The majority of GD applications involve genetic engineering and novel traits. Therefore, applicants and GMO regulators need to interact to achieve the benefits in innovation while cautiously avoiding unacceptable risks. The release into the environment may include transboundary movement and replacement of target populations, with potential impact on human/animal health and the environment. This article summarizes knowledge-based discussions to identify information gaps and analyzes scenarios for responsible introduction of GD organisms into the environment. It aims to connect the latest scientific developments with regulatory approaches and decision-making.https://www.frontiersin.org/article/10.3389/fbioe.2019.00454/fullgenome editinggene driveenvironmental risk assessment (ERA)regulationinvasive species |
| spellingShingle | Heidi J. Mitchell Detlef Bartsch Regulation of GM Organisms for Invasive Species Control Frontiers in Bioengineering and Biotechnology genome editing gene drive environmental risk assessment (ERA) regulation invasive species |
| title | Regulation of GM Organisms for Invasive Species Control |
| title_full | Regulation of GM Organisms for Invasive Species Control |
| title_fullStr | Regulation of GM Organisms for Invasive Species Control |
| title_full_unstemmed | Regulation of GM Organisms for Invasive Species Control |
| title_short | Regulation of GM Organisms for Invasive Species Control |
| title_sort | regulation of gm organisms for invasive species control |
| topic | genome editing gene drive environmental risk assessment (ERA) regulation invasive species |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2019.00454/full |
| work_keys_str_mv | AT heidijmitchell regulationofgmorganismsforinvasivespeciescontrol AT detlefbartsch regulationofgmorganismsforinvasivespeciescontrol |