Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome
Objective Previous studies have questioned the safety and efficacy of minor salivary gland biopsy in the diagnosis of Sjögren’s syndrome, citing complications and difficulty of pathologic evaluation. This study aims to determine the rate of biopsy specimen adequacy and the risk of complications afte...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
|
| Series: | OTO Open |
| Online Access: | https://doi.org/10.1177/2473974X221116107 |
| _version_ | 1797642343799586816 |
|---|---|
| author | Alex J. Gordon Aneek Patel Fang Zhou MD Cheng Liu MD Amit Saxena MD Paula Rackoff MD Babak Givi MD |
| author_facet | Alex J. Gordon Aneek Patel Fang Zhou MD Cheng Liu MD Amit Saxena MD Paula Rackoff MD Babak Givi MD |
| author_sort | Alex J. Gordon |
| collection | DOAJ |
| description | Objective Previous studies have questioned the safety and efficacy of minor salivary gland biopsy in the diagnosis of Sjögren’s syndrome, citing complications and difficulty of pathologic evaluation. This study aims to determine the rate of biopsy specimen adequacy and the risk of complications after minor salivary gland biopsy. Study Design Case series. Setting Single tertiary care center. Methods We reviewed the records of all patients who underwent minor salivary gland biopsy at our institution from October 1, 2016, to September 1, 2021. Demographics, comorbidities, symptoms, and serologic results were recorded. The primary outcome was adequacy of the tissue sample. Complications of the procedure were recorded. Biopsies with at least one focus of ≥50 lymphocytes per 4-mm 2 sample were considered positive. Results We identified 110 patients who underwent minor salivary gland biopsy. Ninety-three (85%) were female, and the median age was 49.1 years (range, 18.7-80.5). Seventy-seven procedures (70%) were performed in the office setting, and 33 (30%) were performed in the operating room. Nearly all biopsy samples (n = 108, 98%) were adequate, and 33 (31%) were interpreted as positive. Four patients (4%) experienced temporary lip numbness, which resolved with conservative management. No permanent complications were reported after lip biopsy. Nineteen (58%) patients with positive biopsy results had no Sjögren’s-specific antibodies. Most patients with positive biopsy results (n = 20, 61%) subsequently started immunomodulatory therapy. Conclusion Minor salivary gland biopsy can be performed safely and effectively in both the office and the operating room. This procedure provides clinically meaningful information and can be reasonably recommended in patients suspected to have Sjögren’s syndrome. |
| first_indexed | 2024-03-11T13:58:43Z |
| format | Article |
| id | doaj.art-fdf027dfe42b48f5a6de505f2ff30e78 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-03-11T13:58:43Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-fdf027dfe42b48f5a6de505f2ff30e782023-11-02T05:51:00ZengWileyOTO Open2473-974X2022-07-01610.1177/2473974X221116107Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s SyndromeAlex J. Gordon0Aneek Patel1Fang Zhou MD2Cheng Liu MD3Amit Saxena MD4Paula Rackoff MD5Babak Givi MD6Department of Otolaryngology–Head and Neck Surgery, NYU Langone Health, New York, New York, USADepartment of Otolaryngology–Head and Neck Surgery, NYU Langone Health, New York, New York, USADepartment of Pathology, NYU Langone Health, New York, New York, USADepartment of Pathology, NYU Langone Health, New York, New York, USADivision of Rheumatology, Department of Medicine, NYU Langone Health, New York, New York, USADivision of Rheumatology, Department of Medicine, NYU Langone Health, New York, New York, USADepartment of Otolaryngology–Head and Neck Surgery, NYU Langone Health, New York, New York, USAObjective Previous studies have questioned the safety and efficacy of minor salivary gland biopsy in the diagnosis of Sjögren’s syndrome, citing complications and difficulty of pathologic evaluation. This study aims to determine the rate of biopsy specimen adequacy and the risk of complications after minor salivary gland biopsy. Study Design Case series. Setting Single tertiary care center. Methods We reviewed the records of all patients who underwent minor salivary gland biopsy at our institution from October 1, 2016, to September 1, 2021. Demographics, comorbidities, symptoms, and serologic results were recorded. The primary outcome was adequacy of the tissue sample. Complications of the procedure were recorded. Biopsies with at least one focus of ≥50 lymphocytes per 4-mm 2 sample were considered positive. Results We identified 110 patients who underwent minor salivary gland biopsy. Ninety-three (85%) were female, and the median age was 49.1 years (range, 18.7-80.5). Seventy-seven procedures (70%) were performed in the office setting, and 33 (30%) were performed in the operating room. Nearly all biopsy samples (n = 108, 98%) were adequate, and 33 (31%) were interpreted as positive. Four patients (4%) experienced temporary lip numbness, which resolved with conservative management. No permanent complications were reported after lip biopsy. Nineteen (58%) patients with positive biopsy results had no Sjögren’s-specific antibodies. Most patients with positive biopsy results (n = 20, 61%) subsequently started immunomodulatory therapy. Conclusion Minor salivary gland biopsy can be performed safely and effectively in both the office and the operating room. This procedure provides clinically meaningful information and can be reasonably recommended in patients suspected to have Sjögren’s syndrome.https://doi.org/10.1177/2473974X221116107 |
| spellingShingle | Alex J. Gordon Aneek Patel Fang Zhou MD Cheng Liu MD Amit Saxena MD Paula Rackoff MD Babak Givi MD Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome OTO Open |
| title | Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome |
| title_full | Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome |
| title_fullStr | Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome |
| title_full_unstemmed | Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome |
| title_short | Minor Salivary Gland Biopsy in Diagnosis of Sjögren’s Syndrome |
| title_sort | minor salivary gland biopsy in diagnosis of sjogren s syndrome |
| url | https://doi.org/10.1177/2473974X221116107 |
| work_keys_str_mv | AT alexjgordon minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT aneekpatel minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT fangzhoumd minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT chengliumd minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT amitsaxenamd minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT paularackoffmd minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome AT babakgivimd minorsalivaryglandbiopsyindiagnosisofsjogrenssyndrome |