Oncogenes in immune cells as potential therapeutic targets
Gulnur K Zakiryanova,1 Sarah Wheeler,2 Michael R Shurin2 1Department Biophysics and Biomedicine, Faculty Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; 2Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh Medical Center, Pitts...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-04-01
|
| Series: | ImmunoTargets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/oncogenes-in-immune-cells-as-potential-therapeutic-targets-peer-reviewed-article-ITT |
| _version_ | 1811205143684710400 |
|---|---|
| author | Zakiryanova GK Wheeler S Shurin MR |
| author_facet | Zakiryanova GK Wheeler S Shurin MR |
| author_sort | Zakiryanova GK |
| collection | DOAJ |
| description | Gulnur K Zakiryanova,1 Sarah Wheeler,2 Michael R Shurin2 1Department Biophysics and Biomedicine, Faculty Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; 2Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Abstract: The role of deregulated expression of oncogenes and tumor-suppressor genes in tumor development has been intensively investigated for decades. However, expression of oncogenes and their potential role in immune cell defects during carcinogenesis and tumor progression have not been thoroughly assessed. The defects in proto-oncogenes have been well documented and evaluated mostly in tumor cells, despite the fact that proto-oncogenes are expressed in all cells, including cells of the immune system. In this review, key studies from immune-mediated diseases that may be associated with oncogene signaling pathways are refocused to provide groundwork for beginning to understand the effects of oncogenes in and on the cancer-related immune system dysfunction. Keywords: oncogenes, immune cells, NK cells, Myc, cancer |
| first_indexed | 2024-04-12T03:25:41Z |
| format | Article |
| id | doaj.art-fdf4dc0d7d0e48fa87c819a3f25ca5c1 |
| institution | Directory Open Access Journal |
| issn | 2253-1556 |
| language | English |
| last_indexed | 2024-04-12T03:25:41Z |
| publishDate | 2018-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | ImmunoTargets and Therapy |
| spelling | doaj.art-fdf4dc0d7d0e48fa87c819a3f25ca5c12022-12-22T03:49:43ZengDove Medical PressImmunoTargets and Therapy2253-15562018-04-01Volume 7212837709Oncogenes in immune cells as potential therapeutic targetsZakiryanova GKWheeler SShurin MRGulnur K Zakiryanova,1 Sarah Wheeler,2 Michael R Shurin2 1Department Biophysics and Biomedicine, Faculty Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan; 2Division of Clinical Immunopathology, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Abstract: The role of deregulated expression of oncogenes and tumor-suppressor genes in tumor development has been intensively investigated for decades. However, expression of oncogenes and their potential role in immune cell defects during carcinogenesis and tumor progression have not been thoroughly assessed. The defects in proto-oncogenes have been well documented and evaluated mostly in tumor cells, despite the fact that proto-oncogenes are expressed in all cells, including cells of the immune system. In this review, key studies from immune-mediated diseases that may be associated with oncogene signaling pathways are refocused to provide groundwork for beginning to understand the effects of oncogenes in and on the cancer-related immune system dysfunction. Keywords: oncogenes, immune cells, NK cells, Myc, cancer https://www.dovepress.com/oncogenes-in-immune-cells-as-potential-therapeutic-targets-peer-reviewed-article-ITToncogenesimmune cellsNK cellsMyccancer |
| spellingShingle | Zakiryanova GK Wheeler S Shurin MR Oncogenes in immune cells as potential therapeutic targets ImmunoTargets and Therapy oncogenes immune cells NK cells Myc cancer |
| title | Oncogenes in immune cells as potential therapeutic targets |
| title_full | Oncogenes in immune cells as potential therapeutic targets |
| title_fullStr | Oncogenes in immune cells as potential therapeutic targets |
| title_full_unstemmed | Oncogenes in immune cells as potential therapeutic targets |
| title_short | Oncogenes in immune cells as potential therapeutic targets |
| title_sort | oncogenes in immune cells as potential therapeutic targets |
| topic | oncogenes immune cells NK cells Myc cancer |
| url | https://www.dovepress.com/oncogenes-in-immune-cells-as-potential-therapeutic-targets-peer-reviewed-article-ITT |
| work_keys_str_mv | AT zakiryanovagk oncogenesinimmunecellsaspotentialtherapeutictargets AT wheelers oncogenesinimmunecellsaspotentialtherapeutictargets AT shurinmr oncogenesinimmunecellsaspotentialtherapeutictargets |