Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders
The neural circadian system consists of the master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN) communicating time of day cues to the rest of the body including other brain areas that also rhythmically express circadian clock genes. Over the past 16 years, evidence has emerged to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.815700/full |
| _version_ | 1818950289637507072 |
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| author | Callum J. Young David Lyons Hugh D. Piggins |
| author_facet | Callum J. Young David Lyons Hugh D. Piggins |
| author_sort | Callum J. Young |
| collection | DOAJ |
| description | The neural circadian system consists of the master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN) communicating time of day cues to the rest of the body including other brain areas that also rhythmically express circadian clock genes. Over the past 16 years, evidence has emerged to indicate that the habenula of the epithalamus is a candidate extra-SCN circadian oscillator. When isolated from the SCN, the habenula sustains rhythms in clock gene expression and neuronal activity, with the lateral habenula expressing more robust rhythms than the adjacent medial habenula. The lateral habenula is responsive to putative SCN output factors as well as light information conveyed to the perihabenula area. Neuronal activity in the lateral habenula is altered in depression and intriguingly disruptions in circadian rhythms can elevate risk of developing mental health disorders including depression. In this review, we will principally focus on how circadian and light signals affect the lateral habenula and evaluate the possibility that alteration in these influences contribute to mental health disorders. |
| first_indexed | 2024-12-20T09:16:14Z |
| format | Article |
| id | doaj.art-fdf5ea3c89014dac9c6d432715dc1ab2 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T09:16:14Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-fdf5ea3c89014dac9c6d432715dc1ab22022-12-21T19:45:25ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-01-011510.3389/fnbeh.2021.815700815700Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric DisordersCallum J. YoungDavid LyonsHugh D. PigginsThe neural circadian system consists of the master circadian clock in the hypothalamic suprachiasmatic nuclei (SCN) communicating time of day cues to the rest of the body including other brain areas that also rhythmically express circadian clock genes. Over the past 16 years, evidence has emerged to indicate that the habenula of the epithalamus is a candidate extra-SCN circadian oscillator. When isolated from the SCN, the habenula sustains rhythms in clock gene expression and neuronal activity, with the lateral habenula expressing more robust rhythms than the adjacent medial habenula. The lateral habenula is responsive to putative SCN output factors as well as light information conveyed to the perihabenula area. Neuronal activity in the lateral habenula is altered in depression and intriguingly disruptions in circadian rhythms can elevate risk of developing mental health disorders including depression. In this review, we will principally focus on how circadian and light signals affect the lateral habenula and evaluate the possibility that alteration in these influences contribute to mental health disorders.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.815700/fullcircadiandepressionclock geneburst firingepithalamus |
| spellingShingle | Callum J. Young David Lyons Hugh D. Piggins Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders Frontiers in Behavioral Neuroscience circadian depression clock gene burst firing epithalamus |
| title | Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders |
| title_full | Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders |
| title_fullStr | Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders |
| title_full_unstemmed | Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders |
| title_short | Circadian Influences on the Habenula and Their Potential Contribution to Neuropsychiatric Disorders |
| title_sort | circadian influences on the habenula and their potential contribution to neuropsychiatric disorders |
| topic | circadian depression clock gene burst firing epithalamus |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.815700/full |
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