A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports
Objective: To review biochemical parameters, clinical characteristics, demographics, radiological and histopathological findings, treatment modalities and outcomes used to examine patients with coexisting multiple myeloma and prostate adencocarcinoma. Method: The systematic review comprised searc...
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-07-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://ojs.jpma.org.pk/index.php/public_html/article/view/8068 |
| _version_ | 1797773249014136832 |
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| author | Rashid Iqbal Shafi Rehman Mahnoor Sukaina Hameed Ullah Maha Hameed Uzair Chattha |
| author_facet | Rashid Iqbal Shafi Rehman Mahnoor Sukaina Hameed Ullah Maha Hameed Uzair Chattha |
| author_sort | Rashid Iqbal |
| collection | DOAJ |
| description |
Objective: To review biochemical parameters, clinical characteristics, demographics, radiological and histopathological findings, treatment modalities and outcomes used to examine patients with coexisting multiple myeloma and prostate adencocarcinoma.
Method: The systematic review comprised search on PubMed, Google Scholar, Science Direct and the Directory of Open Access Journal databases for case reports published till June 1, 2022. The search was done in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using appropriate key words. Case reports included were those dealing exclusively with human subjects, were published in the English language and had free, full-text, public access. Quality assessment was done using Joanna Briggs Institute's Critical Appraisal Checklist for Case Reports. Data was extracted and the case reports were evaluated for demographic, diagnostic and treatment parameters.
Results: Of the 515 studies initially identified, 5(0.97%) were analysed; all males with mean age 68.6 years (SD= 10.78). The most common symptom reported at presentation was low back pain 3(60%), Osteolytic lesions were seen in 4(80%) patients on imaging with elevated prostate surface antigen levels. Anaemia was found in 3(60%) patients and 2(40%) had thrombocytopenia.
Conclusion: Multiple myeloma and prostate adenocarcinoma can coexist although it is rare. Awareness regarding the possible coexistence of the two prominent cancer types may further help clinicians during their practice in considering multiple myeloma as a differential diagnosis when encountered with patients having osteolytic bony lesions along with elevated levels of prostate-specific antigen.
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| first_indexed | 2024-03-12T22:02:40Z |
| format | Article |
| id | doaj.art-fdf6357edd244568a855a6d68b626418 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-12T22:02:40Z |
| publishDate | 2023-07-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-fdf6357edd244568a855a6d68b6264182023-07-25T04:40:19ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-07-0173810.47391/JPMA.8068A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reportsRashid Iqbal 0Shafi Rehman1Mahnoor Sukaina2Hameed Ullah3Maha Hameed4Uzair Chattha5Department of Medical Technology, Shifa College of Medical Technology, Islamabad, PakistanDepartment of Medical Technology, Shifa College of Medical Technology, Islamabad, PakistanFinal Year MBBS Student, Karachi Medical and Dental College, Karachi, PakistanDepartment of Internal Medicine, Hayatabad Medical Complex, Peshawar, PakistanDepartment of Internal Medicine, Alfaisal University College of Medicine, Riyadh, Saudi ArabiaDepartment of Internal Medicine, Lahore Medical and Dental College, Lahore, Pakistan Objective: To review biochemical parameters, clinical characteristics, demographics, radiological and histopathological findings, treatment modalities and outcomes used to examine patients with coexisting multiple myeloma and prostate adencocarcinoma. Method: The systematic review comprised search on PubMed, Google Scholar, Science Direct and the Directory of Open Access Journal databases for case reports published till June 1, 2022. The search was done in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using appropriate key words. Case reports included were those dealing exclusively with human subjects, were published in the English language and had free, full-text, public access. Quality assessment was done using Joanna Briggs Institute's Critical Appraisal Checklist for Case Reports. Data was extracted and the case reports were evaluated for demographic, diagnostic and treatment parameters. Results: Of the 515 studies initially identified, 5(0.97%) were analysed; all males with mean age 68.6 years (SD= 10.78). The most common symptom reported at presentation was low back pain 3(60%), Osteolytic lesions were seen in 4(80%) patients on imaging with elevated prostate surface antigen levels. Anaemia was found in 3(60%) patients and 2(40%) had thrombocytopenia. Conclusion: Multiple myeloma and prostate adenocarcinoma can coexist although it is rare. Awareness regarding the possible coexistence of the two prominent cancer types may further help clinicians during their practice in considering multiple myeloma as a differential diagnosis when encountered with patients having osteolytic bony lesions along with elevated levels of prostate-specific antigen. https://ojs.jpma.org.pk/index.php/public_html/article/view/8068Multiple myelomasMyelomatosisPlasma cell myelomaProstate neoplasmProstate cancerProstatic cancer |
| spellingShingle | Rashid Iqbal Shafi Rehman Mahnoor Sukaina Hameed Ullah Maha Hameed Uzair Chattha A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports Journal of the Pakistan Medical Association Multiple myelomas Myelomatosis Plasma cell myeloma Prostate neoplasm Prostate cancer Prostatic cancer |
| title | A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports |
| title_full | A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports |
| title_fullStr | A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports |
| title_full_unstemmed | A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports |
| title_short | A challenging diagnosis of rare co-existent multiple myeloma and prostate adenocarcinoma: a systematic review of case reports |
| title_sort | challenging diagnosis of rare co existent multiple myeloma and prostate adenocarcinoma a systematic review of case reports |
| topic | Multiple myelomas Myelomatosis Plasma cell myeloma Prostate neoplasm Prostate cancer Prostatic cancer |
| url | https://ojs.jpma.org.pk/index.php/public_html/article/view/8068 |
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