Preclinical Models of Neuroblastoma—Current Status and Perspectives
Preclinical in vitro and in vivo models remain indispensable tools in cancer research. These classic models, including two- and three-dimensional cell culture techniques and animal models, are crucial for basic and translational studies. However, each model has its own limitations and typically does...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/13/3314 |
| _version_ | 1797592103810760704 |
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| author | Ewa Krawczyk Joanna Kitlińska |
| author_facet | Ewa Krawczyk Joanna Kitlińska |
| author_sort | Ewa Krawczyk |
| collection | DOAJ |
| description | Preclinical in vitro and in vivo models remain indispensable tools in cancer research. These classic models, including two- and three-dimensional cell culture techniques and animal models, are crucial for basic and translational studies. However, each model has its own limitations and typically does not fully recapitulate the course of the human disease. Therefore, there is an urgent need for the development of novel, advanced systems that can allow for efficient evaluation of the mechanisms underlying cancer development and progression, more accurately reflect the disease pathophysiology and complexity, and effectively inform therapeutic decisions for patients. Preclinical models are especially important for rare cancers, such as neuroblastoma, where the availability of patient-derived specimens that could be used for potential therapy evaluation and screening is limited. Neuroblastoma modeling is further complicated by the disease heterogeneity. In this review, we present the current status of preclinical models for neuroblastoma research, discuss their development and characteristics emphasizing strengths and limitations, and describe the necessity of the development of novel, more advanced and clinically relevant approaches. |
| first_indexed | 2024-03-11T01:46:41Z |
| format | Article |
| id | doaj.art-fdf675791bc347ccbf910ae0b6e836b8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:46:41Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fdf675791bc347ccbf910ae0b6e836b82023-11-18T16:15:10ZengMDPI AGCancers2072-66942023-06-011513331410.3390/cancers15133314Preclinical Models of Neuroblastoma—Current Status and PerspectivesEwa Krawczyk0Joanna Kitlińska1Department of Pathology, Center for Cell Reprogramming, Georgetown University Medical Center, Washington, DC 20057, USADepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC 20057, USAPreclinical in vitro and in vivo models remain indispensable tools in cancer research. These classic models, including two- and three-dimensional cell culture techniques and animal models, are crucial for basic and translational studies. However, each model has its own limitations and typically does not fully recapitulate the course of the human disease. Therefore, there is an urgent need for the development of novel, advanced systems that can allow for efficient evaluation of the mechanisms underlying cancer development and progression, more accurately reflect the disease pathophysiology and complexity, and effectively inform therapeutic decisions for patients. Preclinical models are especially important for rare cancers, such as neuroblastoma, where the availability of patient-derived specimens that could be used for potential therapy evaluation and screening is limited. Neuroblastoma modeling is further complicated by the disease heterogeneity. In this review, we present the current status of preclinical models for neuroblastoma research, discuss their development and characteristics emphasizing strengths and limitations, and describe the necessity of the development of novel, more advanced and clinically relevant approaches.https://www.mdpi.com/2072-6694/15/13/3314neuroblastomain vitro cancer modelsanimal cancer modelspreclinical disease models |
| spellingShingle | Ewa Krawczyk Joanna Kitlińska Preclinical Models of Neuroblastoma—Current Status and Perspectives Cancers neuroblastoma in vitro cancer models animal cancer models preclinical disease models |
| title | Preclinical Models of Neuroblastoma—Current Status and Perspectives |
| title_full | Preclinical Models of Neuroblastoma—Current Status and Perspectives |
| title_fullStr | Preclinical Models of Neuroblastoma—Current Status and Perspectives |
| title_full_unstemmed | Preclinical Models of Neuroblastoma—Current Status and Perspectives |
| title_short | Preclinical Models of Neuroblastoma—Current Status and Perspectives |
| title_sort | preclinical models of neuroblastoma current status and perspectives |
| topic | neuroblastoma in vitro cancer models animal cancer models preclinical disease models |
| url | https://www.mdpi.com/2072-6694/15/13/3314 |
| work_keys_str_mv | AT ewakrawczyk preclinicalmodelsofneuroblastomacurrentstatusandperspectives AT joannakitlinska preclinicalmodelsofneuroblastomacurrentstatusandperspectives |