The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats

Propofol addiction has been detected in humans and rats, which may be facilitated by stress. Corticotropin-releasing factor acts through the corticotropin-releasing factor (CRF) receptor-1 (CRF1R) and CRF2 receptor-2 (CRF2R) and is a crucial candidate target for the interaction between stress and dr...

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Bibliographic Details
Main Authors: Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
stress
CRF
D1 receptor
propofol
addiction
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.775209/full

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