Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review
(1) Background: Obstructive sleep apnea (OSA) affects approximately 1% to 5% of children. To date, the main pathophysiological factor is adenotonsillar tissue hypertrophy. As many respiratory viruses can persist in secondary lymphoepithelial organs after upper airway infection, the objective of this...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Children |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9067/10/3/487 |
| _version_ | 1797612672819134464 |
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| author | Elody Aïem Clémence Leblais Laurence Lupi Alain Doglio |
| author_facet | Elody Aïem Clémence Leblais Laurence Lupi Alain Doglio |
| author_sort | Elody Aïem |
| collection | DOAJ |
| description | (1) Background: Obstructive sleep apnea (OSA) affects approximately 1% to 5% of children. To date, the main pathophysiological factor is adenotonsillar tissue hypertrophy. As many respiratory viruses can persist in secondary lymphoepithelial organs after upper airway infection, the objective of this systematic review was to investigate the link between history of viral infections and the risk of pediatric OSA. (2) Methods: Corresponding references were searched electronically (PubMed [MEDLINE], Cochrane Library and Scopus) until 21 November 2022. Prospective or retrospective cohorts, evaluating the children suffering from OSA with history of viral infections and comparing them with children with no history of viral infections written in English, were included. Four independent reviewers selected studies, extracted data, and evaluated the risk of bias using ROBINS-I. (3) Results: Of 1027 potentially eligible articles, four studies (one retrospective, two prospective cohorts and one case-control) were included. (4) Conclusions: Exposure to lower airway infections may precede the diagnosis of pediatric OSA suggesting that respiratory viruses may play a mechanical role in the development of pediatric OSA. Further research is required to improve our understanding of the role of viral infections. Registration: PROSPERO CRD awaiting. |
| first_indexed | 2024-03-11T06:45:18Z |
| format | Article |
| id | doaj.art-fdf864c7d2374e858037f47ca27ed168 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T06:45:18Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-fdf864c7d2374e858037f47ca27ed1682023-11-17T10:20:59ZengMDPI AGChildren2227-90672023-03-0110348710.3390/children10030487Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic ReviewElody Aïem0Clémence Leblais1Laurence Lupi2Alain Doglio3Faculté de Chirurgie Dentaire Odontologie, Université Côte d’Azur, 5 rue du 22e B.C.A, 06000 Nice, FranceInstitut de Médecine Bucco-Dentaire, CHU Nice, 28 Boulevard de Riquier, 06300 Nice, FranceFaculté de Chirurgie Dentaire Odontologie, Université Côte d’Azur, 5 rue du 22e B.C.A, 06000 Nice, FranceLaboratoire Microbiologie Orale, Immunothérapie et Santé (MICORALIS) UPR7354, Campus Saint Jean d’Angely-SJ2, Faculté de Chirurgie Dentaire, 5 rue du 22e B.C.A, 06300 Nice, France(1) Background: Obstructive sleep apnea (OSA) affects approximately 1% to 5% of children. To date, the main pathophysiological factor is adenotonsillar tissue hypertrophy. As many respiratory viruses can persist in secondary lymphoepithelial organs after upper airway infection, the objective of this systematic review was to investigate the link between history of viral infections and the risk of pediatric OSA. (2) Methods: Corresponding references were searched electronically (PubMed [MEDLINE], Cochrane Library and Scopus) until 21 November 2022. Prospective or retrospective cohorts, evaluating the children suffering from OSA with history of viral infections and comparing them with children with no history of viral infections written in English, were included. Four independent reviewers selected studies, extracted data, and evaluated the risk of bias using ROBINS-I. (3) Results: Of 1027 potentially eligible articles, four studies (one retrospective, two prospective cohorts and one case-control) were included. (4) Conclusions: Exposure to lower airway infections may precede the diagnosis of pediatric OSA suggesting that respiratory viruses may play a mechanical role in the development of pediatric OSA. Further research is required to improve our understanding of the role of viral infections. Registration: PROSPERO CRD awaiting.https://www.mdpi.com/2227-9067/10/3/487obstructive sleep apneapediatricviral infectionsassociationsystematic review |
| spellingShingle | Elody Aïem Clémence Leblais Laurence Lupi Alain Doglio Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review Children obstructive sleep apnea pediatric viral infections association systematic review |
| title | Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review |
| title_full | Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review |
| title_fullStr | Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review |
| title_full_unstemmed | Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review |
| title_short | Is There an Association between Viral Infections and Risk for Pediatric Obstructive Sleep Apnea? A Systematic Review |
| title_sort | is there an association between viral infections and risk for pediatric obstructive sleep apnea a systematic review |
| topic | obstructive sleep apnea pediatric viral infections association systematic review |
| url | https://www.mdpi.com/2227-9067/10/3/487 |
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