Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia.
Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading candidate gene for schizophrenia and related psychiatric conditions, in cognitive function. Altered expression of DISC1 and DISC1-interactor...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4062455?pdf=render |
| _version_ | 1818290075456241664 |
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| author | Antonio Rampino Rosie May Walker Helen Scott Torrance Susan Maguire Anderson Leonardo Fazio Annabella Di Giorgio Paolo Taurisano Barbara Gelao Raffaella Romano Rita Masellis Gianluca Ursini Grazia Caforio Giuseppe Blasi J Kirsty Millar David John Porteous Pippa Ann Thomson Alessandro Bertolino Kathryn Louise Evans |
| author_facet | Antonio Rampino Rosie May Walker Helen Scott Torrance Susan Maguire Anderson Leonardo Fazio Annabella Di Giorgio Paolo Taurisano Barbara Gelao Raffaella Romano Rita Masellis Gianluca Ursini Grazia Caforio Giuseppe Blasi J Kirsty Millar David John Porteous Pippa Ann Thomson Alessandro Bertolino Kathryn Louise Evans |
| author_sort | Antonio Rampino |
| collection | DOAJ |
| description | Cognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading candidate gene for schizophrenia and related psychiatric conditions, in cognitive function. Altered expression of DISC1 and DISC1-interactors has been identified in schizophrenia. Dysregulated expression of DISC1-interactome genes might, therefore, contribute to schizophrenia susceptibility via disruption of molecular systems required for normal cognitive function. Here, the blood RNA expression levels of DISC1 and DISC1-interacting proteins were measured in 63 control subjects. Cognitive function was assessed using neuropsychiatric tests and functional magnetic resonance imaging was used to assess the activity of prefrontal cortical regions during the N-back working memory task, which is abnormal in schizophrenia. Pairwise correlations between gene expression levels and the relationship between gene expression levels and cognitive function and N-back-elicited brain activity were assessed. Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects. We found that DISC1-interactome genes showed correlated expression in the blood of healthy individuals. The expression levels of several interactome members were correlated with cognitive performance and N-back-elicited activity in the prefrontal cortex. In addition, DISC1 and NDEL1 showed decreased expression in schizophrenic subjects compared to healthy controls. Our findings highlight the importance of the coordinated expression of DISC1-interactome genes for normal cognitive function and suggest that dysregulated DISC1 and NDEL1 expression might, in part, contribute to susceptibility for schizophrenia via disruption of prefrontal cortex-dependent cognitive functions. |
| first_indexed | 2024-12-13T02:22:24Z |
| format | Article |
| id | doaj.art-fdf902869c004f15b99e0fd9ecc940ca |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T02:22:24Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-fdf902869c004f15b99e0fd9ecc940ca2022-12-22T00:02:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9989210.1371/journal.pone.0099892Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia.Antonio RampinoRosie May WalkerHelen Scott TorranceSusan Maguire AndersonLeonardo FazioAnnabella Di GiorgioPaolo TaurisanoBarbara GelaoRaffaella RomanoRita MasellisGianluca UrsiniGrazia CaforioGiuseppe BlasiJ Kirsty MillarDavid John PorteousPippa Ann ThomsonAlessandro BertolinoKathryn Louise EvansCognitive dysfunction is central to the schizophrenia phenotype. Genetic and functional studies have implicated Disrupted-in-Schizophrenia 1 (DISC1), a leading candidate gene for schizophrenia and related psychiatric conditions, in cognitive function. Altered expression of DISC1 and DISC1-interactors has been identified in schizophrenia. Dysregulated expression of DISC1-interactome genes might, therefore, contribute to schizophrenia susceptibility via disruption of molecular systems required for normal cognitive function. Here, the blood RNA expression levels of DISC1 and DISC1-interacting proteins were measured in 63 control subjects. Cognitive function was assessed using neuropsychiatric tests and functional magnetic resonance imaging was used to assess the activity of prefrontal cortical regions during the N-back working memory task, which is abnormal in schizophrenia. Pairwise correlations between gene expression levels and the relationship between gene expression levels and cognitive function and N-back-elicited brain activity were assessed. Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects. We found that DISC1-interactome genes showed correlated expression in the blood of healthy individuals. The expression levels of several interactome members were correlated with cognitive performance and N-back-elicited activity in the prefrontal cortex. In addition, DISC1 and NDEL1 showed decreased expression in schizophrenic subjects compared to healthy controls. Our findings highlight the importance of the coordinated expression of DISC1-interactome genes for normal cognitive function and suggest that dysregulated DISC1 and NDEL1 expression might, in part, contribute to susceptibility for schizophrenia via disruption of prefrontal cortex-dependent cognitive functions.http://europepmc.org/articles/PMC4062455?pdf=render |
| spellingShingle | Antonio Rampino Rosie May Walker Helen Scott Torrance Susan Maguire Anderson Leonardo Fazio Annabella Di Giorgio Paolo Taurisano Barbara Gelao Raffaella Romano Rita Masellis Gianluca Ursini Grazia Caforio Giuseppe Blasi J Kirsty Millar David John Porteous Pippa Ann Thomson Alessandro Bertolino Kathryn Louise Evans Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. PLoS ONE |
| title | Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. |
| title_full | Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. |
| title_fullStr | Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. |
| title_full_unstemmed | Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. |
| title_short | Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. |
| title_sort | expression of disc1 interactome members correlates with cognitive phenotypes related to schizophrenia |
| url | http://europepmc.org/articles/PMC4062455?pdf=render |
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