An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications
Modulations of fluid flow inside the bone intramedullary cavity has been found to stimulate bone cellular activities and augment bone growth. However, study on the efficacy of the fluid modulation has been limited to external syringe pumps connected to the bone intramedullary cavity through the skin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/11/3/300 |
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| author | Ziyu Chen Sunggi Noh Rhonda D. Prisby Jeong-Bong Lee |
| author_facet | Ziyu Chen Sunggi Noh Rhonda D. Prisby Jeong-Bong Lee |
| author_sort | Ziyu Chen |
| collection | DOAJ |
| description | Modulations of fluid flow inside the bone intramedullary cavity has been found to stimulate bone cellular activities and augment bone growth. However, study on the efficacy of the fluid modulation has been limited to external syringe pumps connected to the bone intramedullary cavity through the skin tubing. We report an implantable magnetic microfluidic pump which is suitable for in vivo studies in rodents. A compact microfluidic pump (22 mm diameter, 5 mm in thickness) with NdFeB magnets was fabricated in polydimethylsiloxane (PDMS) using a set of stainless-steel molds. An external actuator with a larger magnet was used to wirelessly actuate the magnetic microfluidic pump. The characterization of the static pressure of the microfluidic pump as a function of size of magnets was assessed. The dynamic pressure of the pump was also characterized to estimate the output of the pump. The magnetic microfluidic pump was implanted into the back of a Fischer-344 rat and connected to the intramedullary cavity of the femur using a tube. On-demand wireless magnetic operation using an actuator outside of the body was found to induce pressure modulation of up to 38 mmHg inside the femoral intramedullary cavity of the rat. |
| first_indexed | 2024-12-10T23:10:52Z |
| format | Article |
| id | doaj.art-fdfd39b5a9fe4c8b8f6e15f7d99d5cbd |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-10T23:10:52Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-fdfd39b5a9fe4c8b8f6e15f7d99d5cbd2022-12-22T01:29:58ZengMDPI AGMicromachines2072-666X2020-03-0111330010.3390/mi11030300mi11030300An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling ApplicationsZiyu Chen0Sunggi Noh1Rhonda D. Prisby2Jeong-Bong Lee3Department of Electrical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USADepartment of Kinesiology, The University of Texas at Arlington, Arlington, TX 76019, USADepartment of Kinesiology, The University of Texas at Arlington, Arlington, TX 76019, USADepartment of Electrical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USAModulations of fluid flow inside the bone intramedullary cavity has been found to stimulate bone cellular activities and augment bone growth. However, study on the efficacy of the fluid modulation has been limited to external syringe pumps connected to the bone intramedullary cavity through the skin tubing. We report an implantable magnetic microfluidic pump which is suitable for in vivo studies in rodents. A compact microfluidic pump (22 mm diameter, 5 mm in thickness) with NdFeB magnets was fabricated in polydimethylsiloxane (PDMS) using a set of stainless-steel molds. An external actuator with a larger magnet was used to wirelessly actuate the magnetic microfluidic pump. The characterization of the static pressure of the microfluidic pump as a function of size of magnets was assessed. The dynamic pressure of the pump was also characterized to estimate the output of the pump. The magnetic microfluidic pump was implanted into the back of a Fischer-344 rat and connected to the intramedullary cavity of the femur using a tube. On-demand wireless magnetic operation using an actuator outside of the body was found to induce pressure modulation of up to 38 mmHg inside the femoral intramedullary cavity of the rat.https://www.mdpi.com/2072-666X/11/3/300intramedullary cavitymicrofluidic pumpmagneticimplantable |
| spellingShingle | Ziyu Chen Sunggi Noh Rhonda D. Prisby Jeong-Bong Lee An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications Micromachines intramedullary cavity microfluidic pump magnetic implantable |
| title | An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications |
| title_full | An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications |
| title_fullStr | An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications |
| title_full_unstemmed | An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications |
| title_short | An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications |
| title_sort | implanted magnetic microfluidic pump for in vivo bone remodeling applications |
| topic | intramedullary cavity microfluidic pump magnetic implantable |
| url | https://www.mdpi.com/2072-666X/11/3/300 |
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