Evaluation of Salivary C-Reactive Protein and Psychological Factors in Patients with Oral Lichen Planus: A Cross-sectional Study
Introduction: Aetiology and pathogenesis of Oral Lichen Planus (OLP) has been focus of research since a long time and various aetiological factors like autoimmunity, heredity, drugs, dental materials, psychological factors, especially stress and anxiety have been reported to be associated with t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2021-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14941/47545_CE[Ra1]_F[IK]_PF1(PS_RK_SHU_KM)_PN(KM).pdf |
| Summary: | Introduction: Aetiology and pathogenesis of Oral Lichen Planus
(OLP) has been focus of research since a long time and various
aetiological factors like autoimmunity, heredity, drugs, dental
materials, psychological factors, especially stress and anxiety
have been reported to be associated with this disease. Few
studies in past have found significant elevations in C-Reactive
Protein (CRP) levels in individuals who reported to be having
chronic stress. Both altered salivary CRP levels and psychological
stress have been reported in OLP patients. To the best of our
knowledge no such studies have been conducted in past, so a
need was felt to conduct a study to evaluate and also correlate
salivary CRP and psychological factors in OLP patients.
Aim: To evaluate salivary CRP and psychological factors and
assess only possible correlation between them in patients
with OLP.
Materials and Methods: This cross-sectional study included
of two groups: Group A- consisting of 33 individuals clinically
diagnosed with OLP and Group B- consisting of 33, age and
gender matched healthy individuals. Hospital Anxiety and
Depression Scale (HADS) was used for all the participants to
evaluate the psychological factors. Salivary CRP levels were
evaluated using Mispa i2 Nephelometry. Statistical analysis was
done using SPSS software.
Results: Mean salivary CRP value among cases was
3.42±2.786 and among controls was 2.84±.848. Mean HADS
score among cases was 6.60±2.796 and among controls was
2.70±.948. Mean Salivary CRP and HADS values were higher
in OLP patients compared to controls. However, no statistical
significant association could be established between CRP and
HADS in patients with OLP (p=0.200).
Conclusion: No correlation between psychological status
and CRP levels could be established in patients with
OLP. CRP could be used as a diagnostic marker in oral
premalignant lesions. |
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| ISSN: | 2249-782X 0973-709X |