Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts
Deep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03777-z |
| _version_ | 1798038813593829376 |
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| author | Agnieszka Brojakowska Anupreet Kour Mark Charles Thel Eunbee Park Malik Bisserier Venkata Naga Srikanth Garikipati Lahouaria Hadri Paul J. Mills Kenneth Walsh David A. Goukassian |
| author_facet | Agnieszka Brojakowska Anupreet Kour Mark Charles Thel Eunbee Park Malik Bisserier Venkata Naga Srikanth Garikipati Lahouaria Hadri Paul J. Mills Kenneth Walsh David A. Goukassian |
| author_sort | Agnieszka Brojakowska |
| collection | DOAJ |
| description | Deep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A. |
| first_indexed | 2024-04-11T21:45:29Z |
| format | Article |
| id | doaj.art-fe01dec5bb5e46eb9f473d95d385bd45 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T21:45:29Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-fe01dec5bb5e46eb9f473d95d385bd452022-12-22T04:01:26ZengNature PortfolioCommunications Biology2399-36422022-08-01511610.1038/s42003-022-03777-zRetrospective analysis of somatic mutations and clonal hematopoiesis in astronautsAgnieszka Brojakowska0Anupreet Kour1Mark Charles Thel2Eunbee Park3Malik Bisserier4Venkata Naga Srikanth Garikipati5Lahouaria Hadri6Paul J. Mills7Kenneth Walsh8David A. Goukassian9Cardiovascular Research Institute, Icahn School of Medicine at Mount SinaiHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of MedicineHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of MedicineHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of MedicineCardiovascular Research Institute, Icahn School of Medicine at Mount SinaiDorothy M. Davis Heart Lung and Research Institute and Department of Emergency Medicine, The Ohio State University Wexner Medical CenterCardiovascular Research Institute, Icahn School of Medicine at Mount SinaiCenter of Excellence for Research and Training in Integrative Health, University of California San DiegoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of MedicineCardiovascular Research Institute, Icahn School of Medicine at Mount SinaiDeep targeted DNA sequencing of peripheral blood mononuclear cells isolated from blood samples from 14 astronauts who flew Shuttle missions between 1998–2001 identifies 34 non-silent mutations, predominantly in TP53 and DNMT3A.https://doi.org/10.1038/s42003-022-03777-z |
| spellingShingle | Agnieszka Brojakowska Anupreet Kour Mark Charles Thel Eunbee Park Malik Bisserier Venkata Naga Srikanth Garikipati Lahouaria Hadri Paul J. Mills Kenneth Walsh David A. Goukassian Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts Communications Biology |
| title | Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| title_full | Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| title_fullStr | Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| title_full_unstemmed | Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| title_short | Retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| title_sort | retrospective analysis of somatic mutations and clonal hematopoiesis in astronauts |
| url | https://doi.org/10.1038/s42003-022-03777-z |
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