Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China?
BackgroundChina had its first wave of COVID-19 in 2020 and second wave of COVID-19 Omicron in 2022. The number of RSV cases decreased sharply in 2020 and 2022. Investigation of the resurge of RSV infections after the first wave of COVID-19 will guide us to take preventive actions before the resurge...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1216536/full |
| _version_ | 1797393439564759040 |
|---|---|
| author | Wujun Jiang Sainan Chen Meng Lv Zhen Zhang Zhihui Wang Xuejun Shao Shenghao Hua Chuangli Hao Yuqing Wang |
| author_facet | Wujun Jiang Sainan Chen Meng Lv Zhen Zhang Zhihui Wang Xuejun Shao Shenghao Hua Chuangli Hao Yuqing Wang |
| author_sort | Wujun Jiang |
| collection | DOAJ |
| description | BackgroundChina had its first wave of COVID-19 in 2020 and second wave of COVID-19 Omicron in 2022. The number of RSV cases decreased sharply in 2020 and 2022. Investigation of the resurge of RSV infections after the first wave of COVID-19 will guide us to take preventive actions before the resurge of RSV infections after the second wave of COVID-19 Omicron.MethodsWe analysed epidemiological and clinical data of 59934 patients with lower respiratory tract infections (LRTI) from a prospective long-term cohort surveillance programme in Suzhou, China, collected from February 2016 to January 2022. The annual incidence of RSV infection in children aged<16 years in 2020 and 2021 was compared with the pre-pandemic years 2016 to 2019. We also compared the clinical characteristics, and RSV-related ICU admissions between pre-pandemic years and 2021.ResultsAmong children with LRTI, the positive rate of RSV increased by 70.7% in 2021 compared to the average level in the pre-pandemic years. The RSV resurge in 2021 was most prominently in children aged 2-4 years (a significant rise compared with the expected value 149.1%; 95%CI, 67.7% to 378%, P<.01). The percentage of RSV-related ICU admissions decreased in 2021 (3.2% vs 6.7%, P<0.01). The death rate of RSV infections in 2021 was 0.2%, while that in pre-pandemic years was only 0.02%. RSV-associated death in immunocompetent children (complicated by necrotizing encephalitis) was firstly occurred in 2021.ConclusionsOur findings raise concerns for RSV control in Southeast China after the COVID-19 pandemic especially for children aged 2-4 years. Although ICU admissions were significantly reduced in this resurgence, we could not ignore the increase of RSV-associated death. |
| first_indexed | 2024-03-09T00:03:34Z |
| format | Article |
| id | doaj.art-fe033cb459414725a7acd990892d4345 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-09T00:03:34Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-fe033cb459414725a7acd990892d43452023-12-12T14:57:53ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-12-011310.3389/fcimb.2023.12165361216536Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China?Wujun Jiang0Sainan Chen1Meng Lv2Zhen Zhang3Zhihui Wang4Xuejun Shao5Shenghao Hua6Chuangli Hao7Yuqing Wang8Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaClinical Laboratory, Children’s Hospital of Soochow University, Suzhou, ChinaClinical Laboratory, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, ChinaBackgroundChina had its first wave of COVID-19 in 2020 and second wave of COVID-19 Omicron in 2022. The number of RSV cases decreased sharply in 2020 and 2022. Investigation of the resurge of RSV infections after the first wave of COVID-19 will guide us to take preventive actions before the resurge of RSV infections after the second wave of COVID-19 Omicron.MethodsWe analysed epidemiological and clinical data of 59934 patients with lower respiratory tract infections (LRTI) from a prospective long-term cohort surveillance programme in Suzhou, China, collected from February 2016 to January 2022. The annual incidence of RSV infection in children aged<16 years in 2020 and 2021 was compared with the pre-pandemic years 2016 to 2019. We also compared the clinical characteristics, and RSV-related ICU admissions between pre-pandemic years and 2021.ResultsAmong children with LRTI, the positive rate of RSV increased by 70.7% in 2021 compared to the average level in the pre-pandemic years. The RSV resurge in 2021 was most prominently in children aged 2-4 years (a significant rise compared with the expected value 149.1%; 95%CI, 67.7% to 378%, P<.01). The percentage of RSV-related ICU admissions decreased in 2021 (3.2% vs 6.7%, P<0.01). The death rate of RSV infections in 2021 was 0.2%, while that in pre-pandemic years was only 0.02%. RSV-associated death in immunocompetent children (complicated by necrotizing encephalitis) was firstly occurred in 2021.ConclusionsOur findings raise concerns for RSV control in Southeast China after the COVID-19 pandemic especially for children aged 2-4 years. Although ICU admissions were significantly reduced in this resurgence, we could not ignore the increase of RSV-associated death.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1216536/fullrespiratory syncytial virus infectionCOVID-19 pandemicchildrensurveillanceintensive care unit |
| spellingShingle | Wujun Jiang Sainan Chen Meng Lv Zhen Zhang Zhihui Wang Xuejun Shao Shenghao Hua Chuangli Hao Yuqing Wang Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? Frontiers in Cellular and Infection Microbiology respiratory syncytial virus infection COVID-19 pandemic children surveillance intensive care unit |
| title | Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? |
| title_full | Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? |
| title_fullStr | Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? |
| title_full_unstemmed | Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? |
| title_short | Are we ready to face the next wave of RSV surge after the COVID-19 Omicron pandemic in China? |
| title_sort | are we ready to face the next wave of rsv surge after the covid 19 omicron pandemic in china |
| topic | respiratory syncytial virus infection COVID-19 pandemic children surveillance intensive care unit |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1216536/full |
| work_keys_str_mv | AT wujunjiang arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT sainanchen arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT menglv arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT zhenzhang arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT zhihuiwang arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT xuejunshao arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT shenghaohua arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT chuanglihao arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina AT yuqingwang arewereadytofacethenextwaveofrsvsurgeafterthecovid19omicronpandemicinchina |