Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors
The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1–8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associat...
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| Format: | Article |
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PeerJ Inc.
2024-01-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/16757.pdf |
| _version_ | 1797356574279204864 |
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| author | Sai-Li Duan Yingke Jiang Guo-Qing Li Weijie Fu Zewen Song Li-Nan Li Jia Li |
| author_facet | Sai-Li Duan Yingke Jiang Guo-Qing Li Weijie Fu Zewen Song Li-Nan Li Jia Li |
| author_sort | Sai-Li Duan |
| collection | DOAJ |
| description | The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1–8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member’s chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers. Furthermore, we discuss several clinically applied tumor therapies targeted at the CMTM family, indicating that CMTM family members could be novel immune checkpoints and potential targets effective in tumor treatment. |
| first_indexed | 2024-03-08T14:29:39Z |
| format | Article |
| id | doaj.art-fe03978273aa4ed8aea76f7f214ff112 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-08T14:29:39Z |
| publishDate | 2024-01-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-fe03978273aa4ed8aea76f7f214ff1122024-01-12T15:05:11ZengPeerJ Inc.PeerJ2167-83592024-01-0112e1675710.7717/peerj.16757Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumorsSai-Li Duan0Yingke Jiang1Guo-Qing Li2Weijie Fu3Zewen Song4Li-Nan Li5Jia Li6Department of General Surgery, Xiangya Hospital Central South University, Changsha Province, Hunan, ChinaDepartment of General Surgery, Xiangya Hospital Central South University, Changsha Province, Hunan, ChinaXiangya School of Medicine, Central South University, Changsha Province, Hunan, ChinaXiangya School of Medicine, Central South University, Changsha Province, Hunan, ChinaDepartment of Oncology, The Third Xiangya Hospital of Central South University, Changsha Province, Hunan, ChinaDepartment of Oncology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Oncology, The 1st Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaThe chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1–8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member’s chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers. Furthermore, we discuss several clinically applied tumor therapies targeted at the CMTM family, indicating that CMTM family members could be novel immune checkpoints and potential targets effective in tumor treatment.https://peerj.com/articles/16757.pdfCMTM familyGene methylationApoptosis pathwayProgrammed death-ligand 1Pancreatic cancerBreast cancer |
| spellingShingle | Sai-Li Duan Yingke Jiang Guo-Qing Li Weijie Fu Zewen Song Li-Nan Li Jia Li Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors PeerJ CMTM family Gene methylation Apoptosis pathway Programmed death-ligand 1 Pancreatic cancer Breast cancer |
| title | Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors |
| title_full | Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors |
| title_fullStr | Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors |
| title_full_unstemmed | Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors |
| title_short | Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors |
| title_sort | research insights into the chemokine like factor cklf like marvel transmembrane domain containing family cmtm their roles in various tumors |
| topic | CMTM family Gene methylation Apoptosis pathway Programmed death-ligand 1 Pancreatic cancer Breast cancer |
| url | https://peerj.com/articles/16757.pdf |
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