The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report
Introduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine wheth...
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| Language: | English |
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Ordem dos Médicos
2020-05-01
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| Series: | Acta Médica Portuguesa |
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| Online Access: | https://actamedicaportuguesa.com/revista/index.php/amp/article/view/12462 |
| _version_ | 1811196422989545472 |
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| author | Diogo Garcia Louisa Spaans Sara Miranda Gilza Gonçalves Joana Reis José Luís Costa Cecília Durães Fátima Carneiro José Carlos Machado |
| author_facet | Diogo Garcia Louisa Spaans Sara Miranda Gilza Gonçalves Joana Reis José Luís Costa Cecília Durães Fátima Carneiro José Carlos Machado |
| author_sort | Diogo Garcia |
| collection | DOAJ |
| description |
Introduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor development, using sporadic and familial adenomatous polyposis related colorectal adenomas as a model.
Material and Methods: The immune tumor-infiltrating cells of a total of 58 low-grade and 18 high-grade colorectal adenomas were examined and compared, using immunostaining for CD3, CD4, CD8, CD57, CD68 and FoxP3.
Results: FoxP3 and CD68 counts were significantly higher in sporadic low-grade dysplasia (p = 0.0003 and p = 0.0103, respectively),and FoxP3 and CD4 counts were found to be significantly higher in high-grade sporadic dysplasia (p = 0.0008 and p = 0.0018, respectively)when compared with corresponding lesions in patients with familial adenomatous polyposis.
Discussion: This study suggests that the immune microenvironment of sporadic and hereditary lesions is different. Sporadic lesions contain a higher number of immune suppressive Treg cells, which suggests a stronger immune selective pressure. In contrast, hereditarylesions seem to benefit from a more tolerant immune microenvironment, allowing for the development of lesions with lower immune cell infiltration.
Conclusion: This study shows that sporadic lesions harbor higher tumor-infiltrating immune cell counts, which might reflect a higher immune tolerance towards hereditary lesions.
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| first_indexed | 2024-04-12T00:58:29Z |
| format | Article |
| id | doaj.art-fe04bc2a5f604f75904729c4b2af11d8 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T00:58:29Z |
| publishDate | 2020-05-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-fe04bc2a5f604f75904729c4b2af11d82022-12-22T03:54:33ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582020-05-0133510.20344/amp.124625073The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series ReportDiogo Garcia0Louisa Spaans1Sara Miranda2Gilza Gonçalves3Joana Reis4José Luís Costa5Cecília Durães6Fátima Carneiro7José Carlos Machado8Medical Faculty. University of Porto. Porto.Maastricht University. Maastricht.Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto.Institute of Molecular Pathology and Immunology. Universidade do Porto. Porto.Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto.Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto.Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto.Medical Faculty. University of Porto. Porto. Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto. Institute of Molecular Pathology and Immunology. Universidade do Porto. Porto. Department of Pathology. Medical Faculty. University of Porto. Porto. Department of Pathology. Centro Hospitalar e Universitário São João. Porto.Medical Faculty. University of Porto. Porto. Instituto de Investigação e Inovação em Saúde. Universidade do Porto. Porto. Institute of Molecular Pathology and Immunology. Universidade do Porto. Porto. Department of Pathology. Medical Faculty. University of Porto. Porto. Introduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor development, using sporadic and familial adenomatous polyposis related colorectal adenomas as a model. Material and Methods: The immune tumor-infiltrating cells of a total of 58 low-grade and 18 high-grade colorectal adenomas were examined and compared, using immunostaining for CD3, CD4, CD8, CD57, CD68 and FoxP3. Results: FoxP3 and CD68 counts were significantly higher in sporadic low-grade dysplasia (p = 0.0003 and p = 0.0103, respectively),and FoxP3 and CD4 counts were found to be significantly higher in high-grade sporadic dysplasia (p = 0.0008 and p = 0.0018, respectively)when compared with corresponding lesions in patients with familial adenomatous polyposis. Discussion: This study suggests that the immune microenvironment of sporadic and hereditary lesions is different. Sporadic lesions contain a higher number of immune suppressive Treg cells, which suggests a stronger immune selective pressure. In contrast, hereditarylesions seem to benefit from a more tolerant immune microenvironment, allowing for the development of lesions with lower immune cell infiltration. Conclusion: This study shows that sporadic lesions harbor higher tumor-infiltrating immune cell counts, which might reflect a higher immune tolerance towards hereditary lesions. https://actamedicaportuguesa.com/revista/index.php/amp/article/view/12462Adenoma/diagnosisAdenoma/geneticsColorectal Neoplasms/diagnosisColorectal Neoplasms/geneticsImmunohistochemistry |
| spellingShingle | Diogo Garcia Louisa Spaans Sara Miranda Gilza Gonçalves Joana Reis José Luís Costa Cecília Durães Fátima Carneiro José Carlos Machado The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report Acta Médica Portuguesa Adenoma/diagnosis Adenoma/genetics Colorectal Neoplasms/diagnosis Colorectal Neoplasms/genetics Immunohistochemistry |
| title | The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report |
| title_full | The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report |
| title_fullStr | The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report |
| title_full_unstemmed | The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report |
| title_short | The Influence of the Genetic and Immunologic Context in the Development of Colorectal Adenoma: A Case Series Report |
| title_sort | influence of the genetic and immunologic context in the development of colorectal adenoma a case series report |
| topic | Adenoma/diagnosis Adenoma/genetics Colorectal Neoplasms/diagnosis Colorectal Neoplasms/genetics Immunohistochemistry |
| url | https://actamedicaportuguesa.com/revista/index.php/amp/article/view/12462 |
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