Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration
Continuous efforts on pursuit of effective drug delivery systems for engineering hydrogel scaffolds is considered a promising strategy for the bone-related diseases. Here, we developed a kind of acetylsalicylic acid (aspirin, ASA)–based double-network (DN) hydrogel containing the positively charged...
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| Format: | Article |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.874985/full |
| _version_ | 1811332056850890752 |
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| author | Wenfeng Zhu Rui Chen Weiheng Wang Yi Liu Changgui Shi Songjun Tang Guoke Tang |
| author_facet | Wenfeng Zhu Rui Chen Weiheng Wang Yi Liu Changgui Shi Songjun Tang Guoke Tang |
| author_sort | Wenfeng Zhu |
| collection | DOAJ |
| description | Continuous efforts on pursuit of effective drug delivery systems for engineering hydrogel scaffolds is considered a promising strategy for the bone-related diseases. Here, we developed a kind of acetylsalicylic acid (aspirin, ASA)–based double-network (DN) hydrogel containing the positively charged natural chitosan (CS) and methacrylated gelatin (GelMA) polymers. Combination of physical chain-entanglement, electrostatic interactions, and a chemically cross-linked methacrylated gelatin (GelMA) network led to the formation of a DN hydrogel, which had a suitable porous structure and favorable mechanical properties. After in situ encapsulation of aspirin agents, the resulting hydrogels were investigated as culturing matrices for adipose tissue–derived stromal cells (ADSCs) to evaluate their excellent biocompatibility and biological capacities on modulation of cell proliferation and differentiation. We further found that the long-term sustained ASA in the DN hydrogels could contribute to the anti-inflammation and osteoinductive properties, demonstrating a new strategy for bone tissue regeneration. |
| first_indexed | 2024-04-13T16:31:03Z |
| format | Article |
| id | doaj.art-fe04eeec6da54dc8b767537fefae3995 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-13T16:31:03Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-fe04eeec6da54dc8b767537fefae39952022-12-22T02:39:35ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-03-011010.3389/fchem.2022.874985874985Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone RegenerationWenfeng Zhu0Rui Chen1Weiheng Wang2Yi Liu3Changgui Shi4Songjun Tang5Guoke Tang6Department of Orthopedics, Shanghai Post and Telecommunication Hospital, Shanghai, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, ChinaDepartment of Orthopedics, Shanghai Post and Telecommunication Hospital, Shanghai, ChinaDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, ChinaContinuous efforts on pursuit of effective drug delivery systems for engineering hydrogel scaffolds is considered a promising strategy for the bone-related diseases. Here, we developed a kind of acetylsalicylic acid (aspirin, ASA)–based double-network (DN) hydrogel containing the positively charged natural chitosan (CS) and methacrylated gelatin (GelMA) polymers. Combination of physical chain-entanglement, electrostatic interactions, and a chemically cross-linked methacrylated gelatin (GelMA) network led to the formation of a DN hydrogel, which had a suitable porous structure and favorable mechanical properties. After in situ encapsulation of aspirin agents, the resulting hydrogels were investigated as culturing matrices for adipose tissue–derived stromal cells (ADSCs) to evaluate their excellent biocompatibility and biological capacities on modulation of cell proliferation and differentiation. We further found that the long-term sustained ASA in the DN hydrogels could contribute to the anti-inflammation and osteoinductive properties, demonstrating a new strategy for bone tissue regeneration.https://www.frontiersin.org/articles/10.3389/fchem.2022.874985/fullDN hydrogelbone regenerationdrug deliveryaspirinGelMA |
| spellingShingle | Wenfeng Zhu Rui Chen Weiheng Wang Yi Liu Changgui Shi Songjun Tang Guoke Tang Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration Frontiers in Chemistry DN hydrogel bone regeneration drug delivery aspirin GelMA |
| title | Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration |
| title_full | Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration |
| title_fullStr | Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration |
| title_full_unstemmed | Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration |
| title_short | Fabrication of Naturally Derived Double-Network Hydrogels With a Sustained Aspirin Release System for Facilitating Bone Regeneration |
| title_sort | fabrication of naturally derived double network hydrogels with a sustained aspirin release system for facilitating bone regeneration |
| topic | DN hydrogel bone regeneration drug delivery aspirin GelMA |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.874985/full |
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