Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity
The present study replicates a known visual language paradigm, and extends it to a paradigm that is independent from the sensory modality of the stimuli and, hence, could be administered either visually or aurally, such that both patients with limited sight or hearing could be examined. The stimuli...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.806520/full |
| _version_ | 1818489774941405184 |
|---|---|
| author | Erik Rødland Erik Rødland Kathrine Midgaard Melleby Kathrine Midgaard Melleby Karsten Specht Karsten Specht Karsten Specht |
| author_facet | Erik Rødland Erik Rødland Kathrine Midgaard Melleby Kathrine Midgaard Melleby Karsten Specht Karsten Specht Karsten Specht |
| author_sort | Erik Rødland |
| collection | DOAJ |
| description | The present study replicates a known visual language paradigm, and extends it to a paradigm that is independent from the sensory modality of the stimuli and, hence, could be administered either visually or aurally, such that both patients with limited sight or hearing could be examined. The stimuli were simple sentences, but required the subject not only to understand the content of the sentence but also to formulate a response that had a semantic relation to the content of the presented sentence. Thereby, this paradigm does not only test perception of the stimuli, but also to some extend sentence and semantic processing, and covert speech production within one task. When the sensory base-line condition was subtracted, both the auditory and visual version of the paradigm demonstrated a broadly overlapping and asymmetric network, comprising distinct areas of the left posterior temporal lobe, left inferior frontal areas, left precentral gyrus, and supplementary motor area. The consistency of activations and their asymmetry was evaluated with a conjunction analysis, probability maps, and intraclass correlation coefficients (ICC). This underlying network was further analyzed with dynamic causal modeling (DCM) to explore whether not only the same brain areas were involved, but also the network structure and information flow were the same between the sensory modalities. In conclusion, the paradigm reliably activated the most central parts of the speech and language network with a great consistency across subjects, and independently of whether the stimuli were administered aurally or visually. However, there was individual variability in the degree of functional asymmetry between the two sensory conditions. |
| first_indexed | 2024-12-10T17:07:59Z |
| format | Article |
| id | doaj.art-fe052aa8aaec49d89b1d682863fb32a2 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-10T17:07:59Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-fe052aa8aaec49d89b1d682863fb32a22022-12-22T01:40:24ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-03-011610.3389/fnbeh.2022.806520806520Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective ConnectivityErik Rødland0Erik Rødland1Kathrine Midgaard Melleby2Kathrine Midgaard Melleby3Karsten Specht4Karsten Specht5Karsten Specht6Department of Biological and Medical Psychology, University of Bergen, Bergen, NorwayDivision of Psychiatry, Department of Child and Adolescent, Haukeland University Hospital, Bergen, NorwayDepartment of Biological and Medical Psychology, University of Bergen, Bergen, NorwayAdult Habilitation Section, Telemark Hospital Skien, Skien, NorwayDepartment of Biological and Medical Psychology, University of Bergen, Bergen, NorwayMohn Medical Imaging and Visualization Centre, Haukeland University Hospital, Bergen, NorwayDepartment of Education, UiT The Arctic University of Norway, Tromsø, NorwayThe present study replicates a known visual language paradigm, and extends it to a paradigm that is independent from the sensory modality of the stimuli and, hence, could be administered either visually or aurally, such that both patients with limited sight or hearing could be examined. The stimuli were simple sentences, but required the subject not only to understand the content of the sentence but also to formulate a response that had a semantic relation to the content of the presented sentence. Thereby, this paradigm does not only test perception of the stimuli, but also to some extend sentence and semantic processing, and covert speech production within one task. When the sensory base-line condition was subtracted, both the auditory and visual version of the paradigm demonstrated a broadly overlapping and asymmetric network, comprising distinct areas of the left posterior temporal lobe, left inferior frontal areas, left precentral gyrus, and supplementary motor area. The consistency of activations and their asymmetry was evaluated with a conjunction analysis, probability maps, and intraclass correlation coefficients (ICC). This underlying network was further analyzed with dynamic causal modeling (DCM) to explore whether not only the same brain areas were involved, but also the network structure and information flow were the same between the sensory modalities. In conclusion, the paradigm reliably activated the most central parts of the speech and language network with a great consistency across subjects, and independently of whether the stimuli were administered aurally or visually. However, there was individual variability in the degree of functional asymmetry between the two sensory conditions.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.806520/fullfunctional magnetic resonance imagingfMRIlanguage networkasymmetryspeech perceptionclinical fMRI |
| spellingShingle | Erik Rødland Erik Rødland Kathrine Midgaard Melleby Kathrine Midgaard Melleby Karsten Specht Karsten Specht Karsten Specht Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity Frontiers in Behavioral Neuroscience functional magnetic resonance imaging fMRI language network asymmetry speech perception clinical fMRI |
| title | Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity |
| title_full | Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity |
| title_fullStr | Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity |
| title_full_unstemmed | Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity |
| title_short | Evaluation of a Simple Clinical Language Paradigm With Respect to Sensory Independency, Functional Asymmetry, and Effective Connectivity |
| title_sort | evaluation of a simple clinical language paradigm with respect to sensory independency functional asymmetry and effective connectivity |
| topic | functional magnetic resonance imaging fMRI language network asymmetry speech perception clinical fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.806520/full |
| work_keys_str_mv | AT erikrødland evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT erikrødland evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT kathrinemidgaardmelleby evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT kathrinemidgaardmelleby evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT karstenspecht evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT karstenspecht evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity AT karstenspecht evaluationofasimpleclinicallanguageparadigmwithrespecttosensoryindependencyfunctionalasymmetryandeffectiveconnectivity |