Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery
The purpose of this research was to prepare floating calcium alginate beads of berberine for targeting the gastric mucosa and prolonging their gastric residence time. The floating beads were prepared by suspending octodecanol and berberine in sodium alginate (SA) solution. The suspension was then dr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/16/12/10347/ |
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| author | Hui Pang Were L.L. Munyendo Sheng-Liang Zhu Hui-Xia Lv Zhen-Hai Zhang Yong-Shun Sun |
| author_facet | Hui Pang Were L.L. Munyendo Sheng-Liang Zhu Hui-Xia Lv Zhen-Hai Zhang Yong-Shun Sun |
| author_sort | Hui Pang |
| collection | DOAJ |
| description | The purpose of this research was to prepare floating calcium alginate beads of berberine for targeting the gastric mucosa and prolonging their gastric residence time. The floating beads were prepared by suspending octodecanol and berberine in sodium alginate (SA) solution. The suspension was then dripped into a solution of calcium chloride. The hydrophobic and low-density octodecanol enhanced the sustained-release properties and floating ability of the beads. The bead formulation was optimized for different weight ratios of octodecanol and SA and evaluated in terms of diameter, floating ability and drug loading, entrapment and release. In vitro release studies showed that the floating and sustained release time were effectively increased in gastric media by addition of octodecanol. In vivo studies with rats showed that a significant increase in gastric residence time of beads had been achieved. |
| first_indexed | 2024-04-12T18:31:38Z |
| format | Article |
| id | doaj.art-fe06dead87b94ad7b7f36483e35fc6da |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T18:31:38Z |
| publishDate | 2011-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-fe06dead87b94ad7b7f36483e35fc6da2022-12-22T03:21:04ZengMDPI AGMolecules1420-30492011-12-011612103471035610.3390/molecules161210347Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific DeliveryHui PangWere L.L. MunyendoSheng-Liang ZhuHui-Xia LvZhen-Hai ZhangYong-Shun SunThe purpose of this research was to prepare floating calcium alginate beads of berberine for targeting the gastric mucosa and prolonging their gastric residence time. The floating beads were prepared by suspending octodecanol and berberine in sodium alginate (SA) solution. The suspension was then dripped into a solution of calcium chloride. The hydrophobic and low-density octodecanol enhanced the sustained-release properties and floating ability of the beads. The bead formulation was optimized for different weight ratios of octodecanol and SA and evaluated in terms of diameter, floating ability and drug loading, entrapment and release. In vitro release studies showed that the floating and sustained release time were effectively increased in gastric media by addition of octodecanol. In vivo studies with rats showed that a significant increase in gastric residence time of beads had been achieved.http://www.mdpi.com/1420-3049/16/12/10347/berberineoctodecanolcalcium alginate beadsbuoyancygastric residence |
| spellingShingle | Hui Pang Were L.L. Munyendo Sheng-Liang Zhu Hui-Xia Lv Zhen-Hai Zhang Yong-Shun Sun Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery Molecules berberine octodecanol calcium alginate beads buoyancy gastric residence |
| title | Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery |
| title_full | Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery |
| title_fullStr | Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery |
| title_full_unstemmed | Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery |
| title_short | Preparation and Evaluation of Berberine Alginate Beads for Stomach-Specific Delivery |
| title_sort | preparation and evaluation of berberine alginate beads for stomach specific delivery |
| topic | berberine octodecanol calcium alginate beads buoyancy gastric residence |
| url | http://www.mdpi.com/1420-3049/16/12/10347/ |
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