Twenty-five years of natural products research in NuBBE
The richness of Brazilian biodiversity translates into a valuable collection of molecules with biological properties that range from ecological functions to pharmacological properties. For over 25 years, the Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE) has conduc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Natural Products |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fntpr.2023.1252092/full |
| _version_ | 1797687160750473216 |
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| author | Helena Mannochio-Russo Helena Mannochio-Russo Ana Letícia Pires dos Santos Paula Carolina Pires Bueno Paula Carolina Pires Bueno Rafael Vieira Rafael Vieira Meri Emili Ferreira Pinto Suzana Aparecida Silva Queiroz Luiz Antonio Dutra Lidiane Gaspareto Felippe Andrea Nastri de Luca Batista Tatiana Maria de Souza-Moreira Marilia Valli Rebeca Previate Medina Angela Regina Araujo Alan Cesar Pilon Ian Castro-Gamboa Alberto José Cavalheiro Dulce Helena Siqueira Silva Maysa Furlan Vanderlan da Silva Bolzani |
| author_facet | Helena Mannochio-Russo Helena Mannochio-Russo Ana Letícia Pires dos Santos Paula Carolina Pires Bueno Paula Carolina Pires Bueno Rafael Vieira Rafael Vieira Meri Emili Ferreira Pinto Suzana Aparecida Silva Queiroz Luiz Antonio Dutra Lidiane Gaspareto Felippe Andrea Nastri de Luca Batista Tatiana Maria de Souza-Moreira Marilia Valli Rebeca Previate Medina Angela Regina Araujo Alan Cesar Pilon Ian Castro-Gamboa Alberto José Cavalheiro Dulce Helena Siqueira Silva Maysa Furlan Vanderlan da Silva Bolzani |
| author_sort | Helena Mannochio-Russo |
| collection | DOAJ |
| description | The richness of Brazilian biodiversity translates into a valuable collection of molecules with biological properties that range from ecological functions to pharmacological properties. For over 25 years, the Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE) has conducted extensive investigations into the chemical entities of numerous plant and microorganism species, resulting in the discovery of over a thousand natural compounds spanning various chemical classes (such as shikimate derivatives, phenylpropanoids, terpenoids, alkaloids, and peptides). The research goals within the natural products field encompass phytochemical studies, investigations of endophytic fungi and marine organisms, biosynthetic studies, medicinal chemistry, and the development of innovative methodologies. This comprehensive review article aims to offer valuable insights into the multifaceted research endeavors conducted in NuBBE. In this way, accomplishments, perspectives, and opportunities for advancing natural products research in Brazil are highlighted, seeking to inspire and motivate other research groups in the field of natural products–especially those located in emerging countries with rich biodiversity. |
| first_indexed | 2024-03-12T01:15:15Z |
| format | Article |
| id | doaj.art-fe074be0acc4401593bf144020b97db4 |
| institution | Directory Open Access Journal |
| issn | 2813-2602 |
| language | English |
| last_indexed | 2024-03-12T01:15:15Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Natural Products |
| spelling | doaj.art-fe074be0acc4401593bf144020b97db42023-09-13T18:10:11ZengFrontiers Media S.A.Frontiers in Natural Products2813-26022023-09-01210.3389/fntpr.2023.12520921252092Twenty-five years of natural products research in NuBBEHelena Mannochio-Russo0Helena Mannochio-Russo1Ana Letícia Pires dos Santos2Paula Carolina Pires Bueno3Paula Carolina Pires Bueno4Rafael Vieira5Rafael Vieira6Meri Emili Ferreira Pinto7Suzana Aparecida Silva Queiroz8Luiz Antonio Dutra9Lidiane Gaspareto Felippe10Andrea Nastri de Luca Batista11Tatiana Maria de Souza-Moreira12Marilia Valli13Rebeca Previate Medina14Angela Regina Araujo15Alan Cesar Pilon16Ian Castro-Gamboa17Alberto José Cavalheiro18Dulce Helena Siqueira Silva19Maysa Furlan20Vanderlan da Silva Bolzani21Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, United StatesNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilInstitute of Chemistry, Federal University of Alfenas, Alfenas, Minas Gerais, BrazilLeibniz Institute of Vegetable and Ornamental Crops (IGZ), Grossbeeren, GermanyNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilFederal Institute of Education, Science and Technology of Rondônia, Ji-Paraná, Rondônia, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilDepartment of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Niterói, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilLaboratory of Medicinal and Computational Chemistry (LQMC), Centre for Research and Innovation in Biodiversity and Drug Discovery (CIBFar), Institute of Physics of São Carlos, University of São Paulo (USP), São Carlos, SP, BrazilFederal Institute of Education, Science and Technology of São Paulo, Cubatão, São Paulo, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilNucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE), Department of Biochemistry and Organic Chemistry, Institute of Chemistry, São Paulo State University (UNESP), Araraquara, SP, BrazilThe richness of Brazilian biodiversity translates into a valuable collection of molecules with biological properties that range from ecological functions to pharmacological properties. For over 25 years, the Nucleus of Bioassays, Biosynthesis, and Ecophysiology of Natural Products (NuBBE) has conducted extensive investigations into the chemical entities of numerous plant and microorganism species, resulting in the discovery of over a thousand natural compounds spanning various chemical classes (such as shikimate derivatives, phenylpropanoids, terpenoids, alkaloids, and peptides). The research goals within the natural products field encompass phytochemical studies, investigations of endophytic fungi and marine organisms, biosynthetic studies, medicinal chemistry, and the development of innovative methodologies. This comprehensive review article aims to offer valuable insights into the multifaceted research endeavors conducted in NuBBE. In this way, accomplishments, perspectives, and opportunities for advancing natural products research in Brazil are highlighted, seeking to inspire and motivate other research groups in the field of natural products–especially those located in emerging countries with rich biodiversity.https://www.frontiersin.org/articles/10.3389/fntpr.2023.1252092/fullBrazilian biodiversityisolationbioactivitymethodologiesbiosynthesispeptides |
| spellingShingle | Helena Mannochio-Russo Helena Mannochio-Russo Ana Letícia Pires dos Santos Paula Carolina Pires Bueno Paula Carolina Pires Bueno Rafael Vieira Rafael Vieira Meri Emili Ferreira Pinto Suzana Aparecida Silva Queiroz Luiz Antonio Dutra Lidiane Gaspareto Felippe Andrea Nastri de Luca Batista Tatiana Maria de Souza-Moreira Marilia Valli Rebeca Previate Medina Angela Regina Araujo Alan Cesar Pilon Ian Castro-Gamboa Alberto José Cavalheiro Dulce Helena Siqueira Silva Maysa Furlan Vanderlan da Silva Bolzani Twenty-five years of natural products research in NuBBE Frontiers in Natural Products Brazilian biodiversity isolation bioactivity methodologies biosynthesis peptides |
| title | Twenty-five years of natural products research in NuBBE |
| title_full | Twenty-five years of natural products research in NuBBE |
| title_fullStr | Twenty-five years of natural products research in NuBBE |
| title_full_unstemmed | Twenty-five years of natural products research in NuBBE |
| title_short | Twenty-five years of natural products research in NuBBE |
| title_sort | twenty five years of natural products research in nubbe |
| topic | Brazilian biodiversity isolation bioactivity methodologies biosynthesis peptides |
| url | https://www.frontiersin.org/articles/10.3389/fntpr.2023.1252092/full |
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