Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease
The aim of the present study was to explore the influence of age and gender, on the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in patients with cardiovascular disease (CVD). Fasting tHcy and the MTHFR C67...
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| Format: | Article |
| Language: | English |
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De Gruyter
2010-02-01
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| Series: | Pteridines |
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| Online Access: | https://doi.org/10.1515/pteridines.2010.21.1.103 |
| _version_ | 1830190618347831296 |
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| author | Houcher Zahira Houcher Bakhouche Touabti Abderezak Begag Samia Öztürk Ayşenur Egin Yonca Akar Nejat Djabi Farida |
| author_facet | Houcher Zahira Houcher Bakhouche Touabti Abderezak Begag Samia Öztürk Ayşenur Egin Yonca Akar Nejat Djabi Farida |
| author_sort | Houcher Zahira |
| collection | DOAJ |
| description | The aim of the present study was to explore the influence of age and gender, on the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in patients with cardiovascular disease (CVD). Fasting tHcy and the MTHFR C677T mutation were evaluated in 98 patients with CVD, 46 were men and 52 women (aged 20-96 years). There was a significant elevation of plasma tHcy with age (<45 yr: 33.9 μmol/L vs. >75 yr: 43.6 μmol/L; p <0.01). The mean tHcy concentration increased significantly with age in men (<55 yr: 33.4 μmol/L vs. >55yr: 42.45 μmol/L; p 0.01). However, the plasma tHcy was not increased with older age in women. The frequency of the TT genotype was 19.6% in the younger patients group (>55 yr) compared with 4.7% in the older patients group (>55 yr; p <0.01). In conclusion, the data presented here are consistent with genetic factors that influence tHcy levels being more prominent in old patients (>55 yr). Then, the MTHFR mutation does not seem to be associated with either high tHcy or the occurrence of CVD. |
| first_indexed | 2024-12-17T23:24:47Z |
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| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-12-17T23:24:47Z |
| publishDate | 2010-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-fe08ff39c87b4f10832a4262fbc3fcdf2022-12-21T21:28:48ZengDe GruyterPteridines0933-48072195-47202010-02-0121110310910.1515/pteridines.2010.21.1.103Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular DiseaseHoucher Zahira0Houcher Bakhouche1Touabti Abderezak2Begag Samia3Öztürk Ayşenur4Egin Yonca5Akar Nejat6Djabi Farida7Department of Biology, Faculty of Sciences, University of Sétif, SétifDepartment of Biology, Faculty of Sciences, University of Sétif, Sétif, AlgeriaDepartment of Medicine, Faculty of Medical Sciences; University of Sétif, Sétif, AlgeriaDepartment of Biology, Faculty of Sciences, University of Sétif, SétifPediatric Molecular Genetics Department of Ankara University Medical School, Ankara, TurkeyPediatric Molecular Genetics Department of Ankara University Medical School, Ankara, TurkeyPediatric Molecular Genetics Department of Ankara University Medical School, Ankara, TurkeyDepartment of Medicine, Faculty of Medical Sciences; University of Sétif, Sétif, AlgeriaThe aim of the present study was to explore the influence of age and gender, on the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in patients with cardiovascular disease (CVD). Fasting tHcy and the MTHFR C677T mutation were evaluated in 98 patients with CVD, 46 were men and 52 women (aged 20-96 years). There was a significant elevation of plasma tHcy with age (<45 yr: 33.9 μmol/L vs. >75 yr: 43.6 μmol/L; p <0.01). The mean tHcy concentration increased significantly with age in men (<55 yr: 33.4 μmol/L vs. >55yr: 42.45 μmol/L; p 0.01). However, the plasma tHcy was not increased with older age in women. The frequency of the TT genotype was 19.6% in the younger patients group (>55 yr) compared with 4.7% in the older patients group (>55 yr; p <0.01). In conclusion, the data presented here are consistent with genetic factors that influence tHcy levels being more prominent in old patients (>55 yr). Then, the MTHFR mutation does not seem to be associated with either high tHcy or the occurrence of CVD.https://doi.org/10.1515/pteridines.2010.21.1.103hyperhomocysteinemiamethylenetetrahydrofolate reductasec677t polymorphismcardiovascular diseaseagesexalgeria |
| spellingShingle | Houcher Zahira Houcher Bakhouche Touabti Abderezak Begag Samia Öztürk Ayşenur Egin Yonca Akar Nejat Djabi Farida Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease Pteridines hyperhomocysteinemia methylenetetrahydrofolate reductase c677t polymorphism cardiovascular disease age sex algeria |
| title | Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease |
| title_full | Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease |
| title_fullStr | Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease |
| title_full_unstemmed | Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease |
| title_short | Hyperhomocysteinemia and C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene in Patients with Cardiovascular Disease |
| title_sort | hyperhomocysteinemia and c677t polymorphism of methylenetetrahydrofolate reductase gene in patients with cardiovascular disease |
| topic | hyperhomocysteinemia methylenetetrahydrofolate reductase c677t polymorphism cardiovascular disease age sex algeria |
| url | https://doi.org/10.1515/pteridines.2010.21.1.103 |
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