Extragenital and infectious factors may provoke miscarriage
Adverse reproductive outcome before term is a polyetiological pathology associated with demographic crisis. Some adverse outcomes include perinatal and neonatal infant mortality, major morbidity and mortality of children under two years, violation of psychomotor and physical development, cognitive d...
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| Format: | Article |
| Language: | English |
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National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2023-06-01
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| Series: | The Ukrainian Biochemical Journal |
| Subjects: | |
| Online Access: | http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Gutor_95_3.pdf |
| _version_ | 1827788014084947968 |
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| author | T. G. Gutor N. F. Timchenko O. I. Matsyura |
| author_facet | T. G. Gutor N. F. Timchenko O. I. Matsyura |
| author_sort | T. G. Gutor |
| collection | DOAJ |
| description | Adverse reproductive outcome before term is a polyetiological pathology associated with demographic crisis. Some adverse outcomes include perinatal and neonatal infant mortality, major morbidity and mortality of children under two years, violation of psychomotor and physical development, cognitive disturbances and disability of children under age five. Finding ways to solve these issues remain a priority. The research involved two female groups. The experimental group included 403 women after the involuntary termination of pregnancy, premature birth or in case of threat of miscarriage; the control group included 402 women with physiological course of pregnancy and parturient with full-term pregnancy. The study required the application of systemic approaches and methods including structural, logical, medical and statistical analyses. The survey revealed more than 20 infectious risk factors and more than 70 factors of extragenital origin. The most significant infectious pathologies included COVID-19 (36.23 ± 2.29% and 14.93 ± 1.78%), herpes type 1 (5.96 ± 1.18% and 1.0 ± 0.50%), toxoplasmosis (4.22 ± 1.0% and 1.0 ± 0.50%) and chlamydial infection (4.22 ± 1.0% 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). The most significant extragenital pathologies involved autoimmune thyroiditis (8.68 ± 1.40% and 0.75 ± 0.43%), type 1 diabetes mellitus (2.23 ± 0.74% and 0%) and allergic rhinitis/sinusitis (3.97 ± 0.97% and 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). Obtained results will be used in the development of a personified risk-oriented model for the prevention of preterm pregnancy loss. |
| first_indexed | 2024-03-11T16:59:54Z |
| format | Article |
| id | doaj.art-fe0a8fe9404f4dff8559e654eb50c630 |
| institution | Directory Open Access Journal |
| issn | 2409-4943 2413-5003 |
| language | English |
| last_indexed | 2024-03-11T16:59:54Z |
| publishDate | 2023-06-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | The Ukrainian Biochemical Journal |
| spelling | doaj.art-fe0a8fe9404f4dff8559e654eb50c6302023-10-20T12:13:20ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryThe Ukrainian Biochemical Journal2409-49432413-50032023-06-01953424810.15407/ubj95.03.042Extragenital and infectious factors may provoke miscarriageT. G. Gutor0https://orcid.org/0000-0002-3754-578XN. F. Timchenko1https://orcid.org/0000-0002-4709-226XO. I. Matsyura2https://orcid.org/0000-0003-2656-259XDepartment of Social Medicine, Economics and Organization of Health Care, Danylo Halytsky Lviv National Medical University, Lviv, UkraineDepartment of Social Medicine, Economics and Organization of Health Care, Danylo Halytsky Lviv National Medical University, Lviv, UkraineDepartment of Pediatrics №2, Danylo Halytsky Lviv National Medical University, Lviv, UkraineAdverse reproductive outcome before term is a polyetiological pathology associated with demographic crisis. Some adverse outcomes include perinatal and neonatal infant mortality, major morbidity and mortality of children under two years, violation of psychomotor and physical development, cognitive disturbances and disability of children under age five. Finding ways to solve these issues remain a priority. The research involved two female groups. The experimental group included 403 women after the involuntary termination of pregnancy, premature birth or in case of threat of miscarriage; the control group included 402 women with physiological course of pregnancy and parturient with full-term pregnancy. The study required the application of systemic approaches and methods including structural, logical, medical and statistical analyses. The survey revealed more than 20 infectious risk factors and more than 70 factors of extragenital origin. The most significant infectious pathologies included COVID-19 (36.23 ± 2.29% and 14.93 ± 1.78%), herpes type 1 (5.96 ± 1.18% and 1.0 ± 0.50%), toxoplasmosis (4.22 ± 1.0% and 1.0 ± 0.50%) and chlamydial infection (4.22 ± 1.0% 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). The most significant extragenital pathologies involved autoimmune thyroiditis (8.68 ± 1.40% and 0.75 ± 0.43%), type 1 diabetes mellitus (2.23 ± 0.74% and 0%) and allergic rhinitis/sinusitis (3.97 ± 0.97% and 0.50 ± 0.35%) in the experimental and control groups, respectively (P < 0.01). Obtained results will be used in the development of a personified risk-oriented model for the prevention of preterm pregnancy loss.http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Gutor_95_3.pdfadverse reproductive outcomes before termextragenital pathologyinfectious pathologyrisk factorsrisk-oriented model |
| spellingShingle | T. G. Gutor N. F. Timchenko O. I. Matsyura Extragenital and infectious factors may provoke miscarriage The Ukrainian Biochemical Journal adverse reproductive outcomes before term extragenital pathology infectious pathology risk factors risk-oriented model |
| title | Extragenital and infectious factors may provoke miscarriage |
| title_full | Extragenital and infectious factors may provoke miscarriage |
| title_fullStr | Extragenital and infectious factors may provoke miscarriage |
| title_full_unstemmed | Extragenital and infectious factors may provoke miscarriage |
| title_short | Extragenital and infectious factors may provoke miscarriage |
| title_sort | extragenital and infectious factors may provoke miscarriage |
| topic | adverse reproductive outcomes before term extragenital pathology infectious pathology risk factors risk-oriented model |
| url | http://ukrbiochemjournal.org/wp-content/uploads/2023/07/Gutor_95_3.pdf |
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