Engineering Viroid Resistance
Viroids are non-encapsidated, non-coding, circular, single-stranded RNAs (ssRNAs). They are classified into the families Pospiviroidae and Avsunviroidae, whose members replicate in the nucleus and chloroplast of plant cells, respectively. Viroids have a wide host range, including crop and ornamental...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/7/2/634 |
| _version_ | 1819056015343091712 |
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| author | Athanasios Dalakouras Elena Dadami Michael Wassenegger |
| author_facet | Athanasios Dalakouras Elena Dadami Michael Wassenegger |
| author_sort | Athanasios Dalakouras |
| collection | DOAJ |
| description | Viroids are non-encapsidated, non-coding, circular, single-stranded RNAs (ssRNAs). They are classified into the families Pospiviroidae and Avsunviroidae, whose members replicate in the nucleus and chloroplast of plant cells, respectively. Viroids have a wide host range, including crop and ornamental plants, and can cause devastating diseases with significant economic losses. Thus, several viroids are world-wide, classified as quarantine pathogens and, hence, there is an urgent need for the development of robust antiviroid strategies. RNA silencing-based technologies seem to be a promising tool in this direction. Here, we review the recent advances concerning the complex interaction of viroids with the host’s RNA silencing machinery, evaluate past and present antiviroid approaches, and finally suggest alternative strategies that could potentially be employed in the future in order to achieve transgenic and non-transgenic viroid-free plants. |
| first_indexed | 2024-12-21T13:16:41Z |
| format | Article |
| id | doaj.art-fe0b7c07a7464d7f9ce179cb17a4f9b5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T13:16:41Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-fe0b7c07a7464d7f9ce179cb17a4f9b52022-12-21T19:02:43ZengMDPI AGViruses1999-49152015-02-017263464610.3390/v7020634v7020634Engineering Viroid ResistanceAthanasios Dalakouras0Elena Dadami1Michael Wassenegger2RLP AgroScience GmbH, AIPlanta-Institute for Plant Research, Neustadt, 67435, GermanyRLP AgroScience GmbH, AIPlanta-Institute for Plant Research, Neustadt, 67435, GermanyRLP AgroScience GmbH, AIPlanta-Institute for Plant Research, Neustadt, Germany and Centre for Organisational Studies (COS) Heidelberg, University of Heidelberg, Heidelberg, 69120, GermanyViroids are non-encapsidated, non-coding, circular, single-stranded RNAs (ssRNAs). They are classified into the families Pospiviroidae and Avsunviroidae, whose members replicate in the nucleus and chloroplast of plant cells, respectively. Viroids have a wide host range, including crop and ornamental plants, and can cause devastating diseases with significant economic losses. Thus, several viroids are world-wide, classified as quarantine pathogens and, hence, there is an urgent need for the development of robust antiviroid strategies. RNA silencing-based technologies seem to be a promising tool in this direction. Here, we review the recent advances concerning the complex interaction of viroids with the host’s RNA silencing machinery, evaluate past and present antiviroid approaches, and finally suggest alternative strategies that could potentially be employed in the future in order to achieve transgenic and non-transgenic viroid-free plants.http://www.mdpi.com/1999-4915/7/2/634RNA interferenceartificial micro RNAstransgenic plants |
| spellingShingle | Athanasios Dalakouras Elena Dadami Michael Wassenegger Engineering Viroid Resistance Viruses RNA interference artificial micro RNAs transgenic plants |
| title | Engineering Viroid Resistance |
| title_full | Engineering Viroid Resistance |
| title_fullStr | Engineering Viroid Resistance |
| title_full_unstemmed | Engineering Viroid Resistance |
| title_short | Engineering Viroid Resistance |
| title_sort | engineering viroid resistance |
| topic | RNA interference artificial micro RNAs transgenic plants |
| url | http://www.mdpi.com/1999-4915/7/2/634 |
| work_keys_str_mv | AT athanasiosdalakouras engineeringviroidresistance AT elenadadami engineeringviroidresistance AT michaelwassenegger engineeringviroidresistance |