Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments
Ultra-compact electron beam technology based on laser wakefield acceleration (LWFA) could have a significant impact on radiotherapy treatments. Recent developments in LWFA high-density regime (HD-LWFA) and low-intensity fiber optically transmitted laser beams could allow for cancer treatments with e...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Photonics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6732/9/6/403 |
| _version_ | 1797483236609228800 |
|---|---|
| author | Dante Roa Jeffrey Kuo Harry Moyses Peter Taborek Toshiki Tajima Gerard Mourou Fuyuhiko Tamanoi |
| author_facet | Dante Roa Jeffrey Kuo Harry Moyses Peter Taborek Toshiki Tajima Gerard Mourou Fuyuhiko Tamanoi |
| author_sort | Dante Roa |
| collection | DOAJ |
| description | Ultra-compact electron beam technology based on laser wakefield acceleration (LWFA) could have a significant impact on radiotherapy treatments. Recent developments in LWFA high-density regime (HD-LWFA) and low-intensity fiber optically transmitted laser beams could allow for cancer treatments with electron beams from a miniature electronic source. Moreover, an electron beam emitted from a tip of a fiber optic channel could lead to new endoscopy-based radiotherapy, which is not currently available. Low-energy (10 keV–1 MeV) LWFA electron beams can be produced by irradiating high-density nano-materials with a low-intensity laser in the range of ~10<sup>14</sup> W/cm<sup>2</sup>. This energy range could be useful in radiotherapy and, specifically, brachytherapy for treating superficial, interstitial, intravascular, and intracavitary tumors. Furthermore, it could unveil the next generation of high-dose-rate brachytherapy systems that are not dependent on radioactive sources, do not require specially designed radiation-shielded rooms for treatment, could be portable, could provide a selection of treatment energies, and would significantly reduce operating costs to a radiation oncology clinic. |
| first_indexed | 2024-03-09T22:44:06Z |
| format | Article |
| id | doaj.art-fe0d0c10f8c9477da60a05b56e13ec32 |
| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-09T22:44:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Photonics |
| spelling | doaj.art-fe0d0c10f8c9477da60a05b56e13ec322023-11-23T18:33:01ZengMDPI AGPhotonics2304-67322022-06-019640310.3390/photonics9060403Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer TreatmentsDante Roa0Jeffrey Kuo1Harry Moyses2Peter Taborek3Toshiki Tajima4Gerard Mourou5Fuyuhiko Tamanoi6Department of Radiation Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine-Medical Center, 101 The City Drive, B-23, Orange, CA 92868, USADepartment of Radiation Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine-Medical Center, 101 The City Drive, B-23, Orange, CA 92868, USADepartment of Radiation Oncology, Chao Family Comprehensive Cancer Center, University of California, Irvine-Medical Center, 101 The City Drive, B-23, Orange, CA 92868, USADepartment of Physics and Astronomy, University of California, Irvine, CA 92697, USADepartment of Physics and Astronomy, University of California, Irvine, CA 92697, USAEcole Polytechnique, 91128 Paliseau, FranceInstitute for Integrated Cell-Materials Science, Institute for Advanced Study, Kyoto University, Kyoto 606-8501, JapanUltra-compact electron beam technology based on laser wakefield acceleration (LWFA) could have a significant impact on radiotherapy treatments. Recent developments in LWFA high-density regime (HD-LWFA) and low-intensity fiber optically transmitted laser beams could allow for cancer treatments with electron beams from a miniature electronic source. Moreover, an electron beam emitted from a tip of a fiber optic channel could lead to new endoscopy-based radiotherapy, which is not currently available. Low-energy (10 keV–1 MeV) LWFA electron beams can be produced by irradiating high-density nano-materials with a low-intensity laser in the range of ~10<sup>14</sup> W/cm<sup>2</sup>. This energy range could be useful in radiotherapy and, specifically, brachytherapy for treating superficial, interstitial, intravascular, and intracavitary tumors. Furthermore, it could unveil the next generation of high-dose-rate brachytherapy systems that are not dependent on radioactive sources, do not require specially designed radiation-shielded rooms for treatment, could be portable, could provide a selection of treatment energies, and would significantly reduce operating costs to a radiation oncology clinic.https://www.mdpi.com/2304-6732/9/6/403LWFAfiber opticsmedicinebrachytherapycancer |
| spellingShingle | Dante Roa Jeffrey Kuo Harry Moyses Peter Taborek Toshiki Tajima Gerard Mourou Fuyuhiko Tamanoi Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments Photonics LWFA fiber optics medicine brachytherapy cancer |
| title | Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments |
| title_full | Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments |
| title_fullStr | Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments |
| title_full_unstemmed | Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments |
| title_short | Fiber-Optic Based Laser Wakefield Accelerated Electron Beams and Potential Applications in Radiotherapy Cancer Treatments |
| title_sort | fiber optic based laser wakefield accelerated electron beams and potential applications in radiotherapy cancer treatments |
| topic | LWFA fiber optics medicine brachytherapy cancer |
| url | https://www.mdpi.com/2304-6732/9/6/403 |
| work_keys_str_mv | AT danteroa fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT jeffreykuo fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT harrymoyses fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT petertaborek fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT toshikitajima fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT gerardmourou fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments AT fuyuhikotamanoi fiberopticbasedlaserwakefieldacceleratedelectronbeamsandpotentialapplicationsinradiotherapycancertreatments |