miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models
MicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated β-catenin, c-My...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124713007869 |
| _version_ | 1818970914137571328 |
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| author | Xiaqin Sun Yu Wu Mingxue Gu Yan Zhang |
| author_facet | Xiaqin Sun Yu Wu Mingxue Gu Yan Zhang |
| author_sort | Xiaqin Sun |
| collection | DOAJ |
| description | MicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated β-catenin, c-Myc, and interferon regulatory factor-9. The increased miR-342-5p downregulates the expression of ankyrin G (AnkG), a protein that is known to play a critical role at the axon initial segment. Thus, a specific miRNA alteration may contribute to AD axonopathy by downregulating AnkG. |
| first_indexed | 2024-12-20T14:44:03Z |
| format | Article |
| id | doaj.art-fe0dd2eb6ce847569bf0b624ef0043ce |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-20T14:44:03Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-fe0dd2eb6ce847569bf0b624ef0043ce2022-12-21T19:37:12ZengElsevierCell Reports2211-12472014-01-016226427010.1016/j.celrep.2013.12.028miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse ModelsXiaqin Sun0Yu Wu1Mingxue Gu2Yan Zhang3State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, ChinaState Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, ChinaState Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, ChinaState Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, ChinaMicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated β-catenin, c-Myc, and interferon regulatory factor-9. The increased miR-342-5p downregulates the expression of ankyrin G (AnkG), a protein that is known to play a critical role at the axon initial segment. Thus, a specific miRNA alteration may contribute to AD axonopathy by downregulating AnkG.http://www.sciencedirect.com/science/article/pii/S2211124713007869 |
| spellingShingle | Xiaqin Sun Yu Wu Mingxue Gu Yan Zhang miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models Cell Reports |
| title | miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models |
| title_full | miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models |
| title_fullStr | miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models |
| title_full_unstemmed | miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models |
| title_short | miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models |
| title_sort | mir 342 5p decreases ankyrin g levels in alzheimer s disease transgenic mouse models |
| url | http://www.sciencedirect.com/science/article/pii/S2211124713007869 |
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