Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential
Abstract Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-00972-7 |
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| author | Huldani Huldani Ahmed Ibraheem Rashid Khikmatulla Negmatovich Turaev Maria Jade Catalan Opulencia Walid Kamal Abdelbasset Dmitry Olegovich Bokov Yasser Fakri Mustafa Moaed E. Al-Gazally Ali Thaeer Hammid Mustafa M. Kadhim Seyed Hossein Ahmadi |
| author_facet | Huldani Huldani Ahmed Ibraheem Rashid Khikmatulla Negmatovich Turaev Maria Jade Catalan Opulencia Walid Kamal Abdelbasset Dmitry Olegovich Bokov Yasser Fakri Mustafa Moaed E. Al-Gazally Ali Thaeer Hammid Mustafa M. Kadhim Seyed Hossein Ahmadi |
| author_sort | Huldani Huldani |
| collection | DOAJ |
| description | Abstract Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed that ConA can bind to several receptors on cancerous and normal cells and modulate the related signaling cascades. The most studied host receptor for ConA is MT1-MMP, responsible for most of the lectin's modulations, ranging from activating immune cells to killing tumor cells. In this study, in addition to studying the effect of ConA on signaling and immune cell function, we will focus on the most up-to-date advancements that unraveled the molecular mechanisms by which ConA can induce autophagy and apoptosis in various cancer cell types, where it has been found that P73 and JAK/STAT3 are the leading players. Moreover, we further discuss the main signaling molecules causing liver injury as the most significant side effect of the lectin injection. Altogether, these findings may shed light on the complex signaling pathways controlling the diverse responses created via ConA treatment, thereby modulating these complex networks to create more potent lectin-based cancer therapy. Video Abstract |
| first_indexed | 2024-04-13T17:18:05Z |
| format | Article |
| id | doaj.art-fe11f22aca7b43969fc414baa0dc68aa |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-13T17:18:05Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-fe11f22aca7b43969fc414baa0dc68aa2022-12-22T02:38:04ZengBMCCell Communication and Signaling1478-811X2022-10-0120111410.1186/s12964-022-00972-7Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potentialHuldani Huldani0Ahmed Ibraheem Rashid1Khikmatulla Negmatovich Turaev2Maria Jade Catalan Opulencia3Walid Kamal Abdelbasset4Dmitry Olegovich Bokov5Yasser Fakri Mustafa6Moaed E. Al-Gazally7Ali Thaeer Hammid8Mustafa M. Kadhim9Seyed Hossein Ahmadi10Department of Physiology, Faculty of Medicine, Lambung Mangkurat UniversityDepartment of Pharmacology, Collage of Medicine, University of BabylonDepartment of Clinical Pharmacology, Samarkand State Medical InstituteCollege of Business Administration, Ajman UniversityDepartment of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz UniversityInstitute of Pharmacy, Sechenov First Moscow State Medical UniversityDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of MosulCollege of Medicine, University of Al-AmeedComputer Engineering Techniques Department, Faculty of Information Technology, Imam Ja’afar Al-Sadiq UniversityDepartment of Dentistry, Kut University CollegeResearch Center for Cell and Molecular Sciences, School of Medicine, Tehran University of Medical SciencesAbstract Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devoted to unveiling the lectin's exact molecular mechanism. It has been revealed that ConA can bind to several receptors on cancerous and normal cells and modulate the related signaling cascades. The most studied host receptor for ConA is MT1-MMP, responsible for most of the lectin's modulations, ranging from activating immune cells to killing tumor cells. In this study, in addition to studying the effect of ConA on signaling and immune cell function, we will focus on the most up-to-date advancements that unraveled the molecular mechanisms by which ConA can induce autophagy and apoptosis in various cancer cell types, where it has been found that P73 and JAK/STAT3 are the leading players. Moreover, we further discuss the main signaling molecules causing liver injury as the most significant side effect of the lectin injection. Altogether, these findings may shed light on the complex signaling pathways controlling the diverse responses created via ConA treatment, thereby modulating these complex networks to create more potent lectin-based cancer therapy. Video Abstracthttps://doi.org/10.1186/s12964-022-00972-7LectinConcanavalin AAnti-neoplastic agentAutophagyApoptosisCancer |
| spellingShingle | Huldani Huldani Ahmed Ibraheem Rashid Khikmatulla Negmatovich Turaev Maria Jade Catalan Opulencia Walid Kamal Abdelbasset Dmitry Olegovich Bokov Yasser Fakri Mustafa Moaed E. Al-Gazally Ali Thaeer Hammid Mustafa M. Kadhim Seyed Hossein Ahmadi Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential Cell Communication and Signaling Lectin Concanavalin A Anti-neoplastic agent Autophagy Apoptosis Cancer |
| title | Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential |
| title_full | Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential |
| title_fullStr | Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential |
| title_full_unstemmed | Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential |
| title_short | Concanavalin A as a promising lectin-based anti-cancer agent: the molecular mechanisms and therapeutic potential |
| title_sort | concanavalin a as a promising lectin based anti cancer agent the molecular mechanisms and therapeutic potential |
| topic | Lectin Concanavalin A Anti-neoplastic agent Autophagy Apoptosis Cancer |
| url | https://doi.org/10.1186/s12964-022-00972-7 |
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