Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation

Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation

Abstract Background Allopurinol is a xanthine oxidase inhibitor that lowers serum uric acid and is used to prevent acute gout flares in patients with gout. Observational and small interventional studies have suggested beneficial cardiovascular effects of allopurinol. Objective To determine whether a...

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Bibliographic Details
Main Authors: Isla S Mackenzie, Christopher J Hawkey, Ian Ford, Nicola Greenlaw, Filippo Pigazzani, Amy Rogers, Allan D Struthers, Alan G Begg, Li Wei, Anthony J Avery, Jaspal S Taggar, Andrew Walker, Suzanne L Duce, Rebecca J Barr, Jennifer S Dumbleton, Evelien D Rooke, Jonathan N Townend, Lewis D Ritchie, Thomas M MacDonald
Format: Article
Language:English
Published: NIHR Journals Library 2024-03-01
Series:Health Technology Assessment
Subjects:
allopurinol
xanthine oxidase
myocardial ischaemia
myocardial infarction
stroke
cause of death
cost-benefit analysis
united kingdom
cardiovascular system
randomised controlled trials
prospective studies
humans
gout
multicentre studies
Online Access:https://doi.org/10.3310/ATTM4092

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