Identifying areas of the visual field important for quality of life in patients with glaucoma.
The purpose of this study was to create a vision-related quality of life (VRQoL) prediction system to identify visual field (VF) test points associated with decreased VRQoL in patients with glaucoma.VRQoL score was surveyed in 164 patients with glaucoma using the 'Sumi questionnaire'. A bi...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3592814?pdf=render |
| _version_ | 1819169056547143680 |
|---|---|
| author | Hiroshi Murata Hiroyo Hirasawa Yuka Aoyama Kenji Sugisaki Makoto Araie Chihiro Mayama Makoto Aihara Ryo Asaoka |
| author_facet | Hiroshi Murata Hiroyo Hirasawa Yuka Aoyama Kenji Sugisaki Makoto Araie Chihiro Mayama Makoto Aihara Ryo Asaoka |
| author_sort | Hiroshi Murata |
| collection | DOAJ |
| description | The purpose of this study was to create a vision-related quality of life (VRQoL) prediction system to identify visual field (VF) test points associated with decreased VRQoL in patients with glaucoma.VRQoL score was surveyed in 164 patients with glaucoma using the 'Sumi questionnaire'. A binocular VF was created from monocular VFs by using the integrated VF (IVF) method. VRQoL score was predicted using the 'Random Forest' method, based on visual acuity (VA) of better and worse eyes (better-eye and worse-eye VA) and total deviation (TD) values from the IVF. For comparison, VRQoL scores were regressed (linear regression) against: (i) mean of TD (IVF MD); (ii) better-eye VA; (iii) worse-eye VA; and (iv) IVF MD and better- and worse-eye VAs. The rank of importance of IVF test points was identified using the Random Forest method.The root mean of squared prediction error associated with the Random Forest method (0.30 to 1.97) was significantly smaller than those with linear regression models (0.34 to 3.38, p<0.05, ten-fold cross validation test). Worse-eye VA was the most important variable in all VRQoL tasks. In general, important VF test points were concentrated along the horizontal meridian. Particular areas of the IVF were important for different tasks: peripheral superior and inferior areas in the left hemifield for the 'letters and sentences' task, peripheral, mid-peripheral and para-central inferior regions for the 'walking' task, the peripheral superior region for the 'going out' task, and a broad scattered area across the IVF for the 'dining' task.The VRQoL prediction model with the Random Forest method enables clinicians to better understand patients' VRQoL based on standard clinical measurements of VA and VF. |
| first_indexed | 2024-12-22T19:13:26Z |
| format | Article |
| id | doaj.art-fe1275f0e61c4dd681d4e177a956bbd9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T19:13:26Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-fe1275f0e61c4dd681d4e177a956bbd92022-12-21T18:15:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5869510.1371/journal.pone.0058695Identifying areas of the visual field important for quality of life in patients with glaucoma.Hiroshi MurataHiroyo HirasawaYuka AoyamaKenji SugisakiMakoto AraieChihiro MayamaMakoto AiharaRyo AsaokaThe purpose of this study was to create a vision-related quality of life (VRQoL) prediction system to identify visual field (VF) test points associated with decreased VRQoL in patients with glaucoma.VRQoL score was surveyed in 164 patients with glaucoma using the 'Sumi questionnaire'. A binocular VF was created from monocular VFs by using the integrated VF (IVF) method. VRQoL score was predicted using the 'Random Forest' method, based on visual acuity (VA) of better and worse eyes (better-eye and worse-eye VA) and total deviation (TD) values from the IVF. For comparison, VRQoL scores were regressed (linear regression) against: (i) mean of TD (IVF MD); (ii) better-eye VA; (iii) worse-eye VA; and (iv) IVF MD and better- and worse-eye VAs. The rank of importance of IVF test points was identified using the Random Forest method.The root mean of squared prediction error associated with the Random Forest method (0.30 to 1.97) was significantly smaller than those with linear regression models (0.34 to 3.38, p<0.05, ten-fold cross validation test). Worse-eye VA was the most important variable in all VRQoL tasks. In general, important VF test points were concentrated along the horizontal meridian. Particular areas of the IVF were important for different tasks: peripheral superior and inferior areas in the left hemifield for the 'letters and sentences' task, peripheral, mid-peripheral and para-central inferior regions for the 'walking' task, the peripheral superior region for the 'going out' task, and a broad scattered area across the IVF for the 'dining' task.The VRQoL prediction model with the Random Forest method enables clinicians to better understand patients' VRQoL based on standard clinical measurements of VA and VF.http://europepmc.org/articles/PMC3592814?pdf=render |
| spellingShingle | Hiroshi Murata Hiroyo Hirasawa Yuka Aoyama Kenji Sugisaki Makoto Araie Chihiro Mayama Makoto Aihara Ryo Asaoka Identifying areas of the visual field important for quality of life in patients with glaucoma. PLoS ONE |
| title | Identifying areas of the visual field important for quality of life in patients with glaucoma. |
| title_full | Identifying areas of the visual field important for quality of life in patients with glaucoma. |
| title_fullStr | Identifying areas of the visual field important for quality of life in patients with glaucoma. |
| title_full_unstemmed | Identifying areas of the visual field important for quality of life in patients with glaucoma. |
| title_short | Identifying areas of the visual field important for quality of life in patients with glaucoma. |
| title_sort | identifying areas of the visual field important for quality of life in patients with glaucoma |
| url | http://europepmc.org/articles/PMC3592814?pdf=render |
| work_keys_str_mv | AT hiroshimurata identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT hiroyohirasawa identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT yukaaoyama identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT kenjisugisaki identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT makotoaraie identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT chihiromayama identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT makotoaihara identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma AT ryoasaoka identifyingareasofthevisualfieldimportantforqualityoflifeinpatientswithglaucoma |