Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model
Studying macrophage biology in the context of a whole living organism provides unique possibilities to understand the contribution of this extremely dynamic cell subset in the reaction to infections, and has revealed the relevance of cellular and molecular processes that are fundamental to the cell-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2014-07-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/7/7/785 |
| _version_ | 1819263536486940672 |
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| author | Vincenzo Torraca Samrah Masud Herman P. Spaink Annemarie H. Meijer |
| author_facet | Vincenzo Torraca Samrah Masud Herman P. Spaink Annemarie H. Meijer |
| author_sort | Vincenzo Torraca |
| collection | DOAJ |
| description | Studying macrophage biology in the context of a whole living organism provides unique possibilities to understand the contribution of this extremely dynamic cell subset in the reaction to infections, and has revealed the relevance of cellular and molecular processes that are fundamental to the cell-mediated innate immune response. In particular, various recently established zebrafish infectious disease models are contributing substantially to our understanding of the mechanisms by which different pathogens interact with macrophages and evade host innate immunity. Transgenic zebrafish lines with fluorescently labeled macrophages and other leukocyte populations enable non-invasive imaging at the optically transparent early life stages. Furthermore, there is a continuously expanding availability of vital reporters for subcellular compartments and for probing activation of immune defense mechanisms. These are powerful tools to visualize the activity of phagocytic cells in real time and shed light on the intriguing paradoxical roles of these cells in both limiting infection and supporting the dissemination of intracellular pathogens. This Review will discuss how several bacterial and fungal infection models in zebrafish embryos have led to new insights into the dynamic molecular and cellular mechanisms at play when pathogens encounter host macrophages. We also describe how these insights are inspiring novel therapeutic strategies for infectious disease treatment. |
| first_indexed | 2024-12-23T20:15:09Z |
| format | Article |
| id | doaj.art-fe14fba2e08d4413aa044cd326bca409 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-23T20:15:09Z |
| publishDate | 2014-07-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-fe14fba2e08d4413aa044cd326bca4092022-12-21T17:32:44ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112014-07-017778579710.1242/dmm.015594015594Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host modelVincenzo TorracaSamrah MasudHerman P. SpainkAnnemarie H. MeijerStudying macrophage biology in the context of a whole living organism provides unique possibilities to understand the contribution of this extremely dynamic cell subset in the reaction to infections, and has revealed the relevance of cellular and molecular processes that are fundamental to the cell-mediated innate immune response. In particular, various recently established zebrafish infectious disease models are contributing substantially to our understanding of the mechanisms by which different pathogens interact with macrophages and evade host innate immunity. Transgenic zebrafish lines with fluorescently labeled macrophages and other leukocyte populations enable non-invasive imaging at the optically transparent early life stages. Furthermore, there is a continuously expanding availability of vital reporters for subcellular compartments and for probing activation of immune defense mechanisms. These are powerful tools to visualize the activity of phagocytic cells in real time and shed light on the intriguing paradoxical roles of these cells in both limiting infection and supporting the dissemination of intracellular pathogens. This Review will discuss how several bacterial and fungal infection models in zebrafish embryos have led to new insights into the dynamic molecular and cellular mechanisms at play when pathogens encounter host macrophages. We also describe how these insights are inspiring novel therapeutic strategies for infectious disease treatment.http://dmm.biologists.org/content/7/7/785Leukocyte biologyInnate immunityInfectious diseaseHost-directed therapyMycobacteriumSalmonellaBurkholderiaStaphylococcusShigellaCandida |
| spellingShingle | Vincenzo Torraca Samrah Masud Herman P. Spaink Annemarie H. Meijer Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model Disease Models & Mechanisms Leukocyte biology Innate immunity Infectious disease Host-directed therapy Mycobacterium Salmonella Burkholderia Staphylococcus Shigella Candida |
| title | Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model |
| title_full | Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model |
| title_fullStr | Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model |
| title_full_unstemmed | Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model |
| title_short | Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model |
| title_sort | macrophage pathogen interactions in infectious diseases new therapeutic insights from the zebrafish host model |
| topic | Leukocyte biology Innate immunity Infectious disease Host-directed therapy Mycobacterium Salmonella Burkholderia Staphylococcus Shigella Candida |
| url | http://dmm.biologists.org/content/7/7/785 |
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