TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2∗ (α6β2-containing), α4β2∗, and α3β4∗ nAChRs, using [125I]-epibatidine binding, whole-cell patch-clamp recordings,...

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Bibliographic Details
Main Authors:	Teagan R. Wall, Brandon J. Henderson, George Voren, Charles R. Wageman, Purnima Deshpande, Bruce N. Cohen, Sharon R. Grady, Michael J. Marks, Daniel Yohannes, Paul J. Kenny, Merouane Bencherif, Henry A. Lester
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-09-01
Series:	Frontiers in Pharmacology
Subjects:	nicotine addiction nicotinic acetylcholine receptors neuroprotection electrophysiology transmitter release α6β2∗
Online Access:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00641/full

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