Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

<p>Abstract</p> <p>Background</p> <p>Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome that is commonly associated with a germline mutation in the tumor suppressor gene <it>p53</it>. Loss of p53 results in increased expression of CD44...

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Bibliographic Details
Main Authors: Yoshida Go J, Fuchimoto Yasushi, Osumi Tomoo, Shimada Hiroyuki, Hosaka Seiichi, Morioka Hideo, Mukai Makio, Masugi Yohei, Sakamoto Michiie, Kuroda Tatsuo
Format: Article
Language:English
Published: BMC 2012-10-01
Series:BMC Cancer
Subjects:
Li-Fraumeni syndrome (LFS)
cancer stem cells (CSCs)
CD44 variant isoforms
Online Access:http://www.biomedcentral.com/1471-2407/12/444

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