An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications
<em>In vitro</em> survival measurements using two human head-and-neck cancer (HNC) cell lines were performed. The specially designed split-dose surviving fraction was obtained and fitted to the linear-quadratic formalism. The repair halftime (Tr), the potential doubling t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/4/2/566 |
| _version_ | 1797764222683185152 |
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| author | X. Allen Li Steve P. Lee Qiuhui Yang X. Sharon Qi Dian Wang |
| author_facet | X. Allen Li Steve P. Lee Qiuhui Yang X. Sharon Qi Dian Wang |
| author_sort | X. Allen Li |
| collection | DOAJ |
| description | <em>In vitro</em> survival measurements using two human head-and-neck cancer (HNC) cell lines were performed. The specially designed split-dose surviving fraction was obtained and fitted to the linear-quadratic formalism. The repair halftime (Tr), the potential doubling time (T<sub>d</sub>), a/β and radiosensitivity a, were estimated. Other radiobiological models: EUD, BED, TCP, <em>etc</em>., were used to examine the potential treatment effectiveness of different IMRT techniques. Our data indicated the repair halftime of ~17 min based on two HNC cell lines. The combined a/β, a and T<sub>d</sub> are a/β = 8.1 ± 4.1 Gy, a = 0.22 ± 0.08 Gy<sup>−1</sup>, T<sub>d</sub> = 4.0 ± 1.8 day, respectively. The prolonged IMRT dose delivery for entire HNC treatment course could possibly result in the loss of biological effectiveness, <em>i.e</em>., the target EUDs decreased by 11% with fraction dose delivery time varying from 5 to 30 min. We determined the sublethal damage repair halftime and other radiobiological parameters for HNC cells, and to evaluate treatment effectiveness of the prolonged dose delivery times associated with different IMRT techniques. The estimated repair halftime for HNC is relatively short and may be comparable to the step-and-shoot IMRT fraction dose delivery time. The effectiveness of IMRT treatment may be improved by reducing the fraction delivery time for HNC treatment. |
| first_indexed | 2024-03-12T19:52:34Z |
| format | Article |
| id | doaj.art-fe189ee5775146588719c735c8275ac2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:52:34Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-fe189ee5775146588719c735c8275ac22023-08-02T03:05:12ZengMDPI AGCancers2072-66942012-06-014256658010.3390/cancers4020566An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical ImplicationsX. Allen LiSteve P. LeeQiuhui YangX. Sharon QiDian Wang<em>In vitro</em> survival measurements using two human head-and-neck cancer (HNC) cell lines were performed. The specially designed split-dose surviving fraction was obtained and fitted to the linear-quadratic formalism. The repair halftime (Tr), the potential doubling time (T<sub>d</sub>), a/β and radiosensitivity a, were estimated. Other radiobiological models: EUD, BED, TCP, <em>etc</em>., were used to examine the potential treatment effectiveness of different IMRT techniques. Our data indicated the repair halftime of ~17 min based on two HNC cell lines. The combined a/β, a and T<sub>d</sub> are a/β = 8.1 ± 4.1 Gy, a = 0.22 ± 0.08 Gy<sup>−1</sup>, T<sub>d</sub> = 4.0 ± 1.8 day, respectively. The prolonged IMRT dose delivery for entire HNC treatment course could possibly result in the loss of biological effectiveness, <em>i.e</em>., the target EUDs decreased by 11% with fraction dose delivery time varying from 5 to 30 min. We determined the sublethal damage repair halftime and other radiobiological parameters for HNC cells, and to evaluate treatment effectiveness of the prolonged dose delivery times associated with different IMRT techniques. The estimated repair halftime for HNC is relatively short and may be comparable to the step-and-shoot IMRT fraction dose delivery time. The effectiveness of IMRT treatment may be improved by reducing the fraction delivery time for HNC treatment.http://www.mdpi.com/2072-6694/4/2/566head-and-neck cancerlinear-quadratic modelsublethal damage repair halftimefraction dose delivery timeintensity modulated radiation therapy |
| spellingShingle | X. Allen Li Steve P. Lee Qiuhui Yang X. Sharon Qi Dian Wang An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications Cancers head-and-neck cancer linear-quadratic model sublethal damage repair halftime fraction dose delivery time intensity modulated radiation therapy |
| title | An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications |
| title_full | An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications |
| title_fullStr | An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications |
| title_full_unstemmed | An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications |
| title_short | An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications |
| title_sort | estimation of radiobiological parameters for head and neck cancer cells and the clinical implications |
| topic | head-and-neck cancer linear-quadratic model sublethal damage repair halftime fraction dose delivery time intensity modulated radiation therapy |
| url | http://www.mdpi.com/2072-6694/4/2/566 |
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