Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds
The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest. Accordingly, there is a demand for straightforward synthetic protocols toward such compounds using re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2022-05-01
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| Series: | SynOpen |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1826-2852 |
| _version_ | 1818484629815951360 |
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| author | Shabber Mohammed Jason S. West Mark J. Mitton-Fry |
| author_facet | Shabber Mohammed Jason S. West Mark J. Mitton-Fry |
| author_sort | Shabber Mohammed |
| collection | DOAJ |
| description | The synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest. Accordingly, there is a demand for straightforward synthetic protocols toward such compounds using readily available starting materials. In the past decade, there have been substantial developments in heterocycle synthesis, especially in metal-catalyzed and iodine-assisted approaches. This graphical review focuses on notable reactions from the past decade using aryl and heteroaryl methyl ketones as starting materials, including representative reaction mechanisms. |
| first_indexed | 2024-12-10T15:57:42Z |
| format | Article |
| id | doaj.art-fe192d89bff14a64b7b754f4d163607a |
| institution | Directory Open Access Journal |
| issn | 2509-9396 |
| language | English |
| last_indexed | 2024-12-10T15:57:42Z |
| publishDate | 2022-05-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | SynOpen |
| spelling | doaj.art-fe192d89bff14a64b7b754f4d163607a2022-12-22T01:42:34ZengGeorg Thieme Verlag KGSynOpen2509-93962022-05-01060211013110.1055/a-1826-2852Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic CompoundsShabber MohammedJason S. WestMark J. Mitton-FryThe synthesis of aromatic heterocycles has attracted substantial attention due to the abundance of these heterocycles in drug molecules, natural products, and other compounds of biological interest. Accordingly, there is a demand for straightforward synthetic protocols toward such compounds using readily available starting materials. In the past decade, there have been substantial developments in heterocycle synthesis, especially in metal-catalyzed and iodine-assisted approaches. This graphical review focuses on notable reactions from the past decade using aryl and heteroaryl methyl ketones as starting materials, including representative reaction mechanisms.http://www.thieme-connect.de/DOI/DOI?10.1055/a-1826-2852aromatic heterocyclesiodineketonesmetal-freefused bicyclesfused tricyclesfused polyheterocycles |
| spellingShingle | Shabber Mohammed Jason S. West Mark J. Mitton-Fry Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds SynOpen aromatic heterocycles iodine ketones metal-free fused bicycles fused tricycles fused polyheterocycles |
| title | Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds |
| title_full | Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds |
| title_fullStr | Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds |
| title_full_unstemmed | Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds |
| title_short | Aryl Methyl Ketones: Versatile Synthons in the Synthesis of Heterocyclic Compounds |
| title_sort | aryl methyl ketones versatile synthons in the synthesis of heterocyclic compounds |
| topic | aromatic heterocycles iodine ketones metal-free fused bicycles fused tricycles fused polyheterocycles |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/a-1826-2852 |
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