Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles
In present study, we assessed the antitumor and antibacterial response of Zn0.5Co0.5Fe2O4 nanoparticles (NPs) synthesized usingsol-gel method. The toxicological mechanism of current smart materials is considered to be valuable keeping in view its many promising applications. The structure, morpholog...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-12-01
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| Series: | Results in Physics |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211379719314664 |
| _version_ | 1818298248119451648 |
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| author | Seemab Iqbal Muhammad Fakhar-e-Alam M. Atif N. Amin K.S. Alimgeer Adnan Ali Aqrab-ul-Ahmad Atif Hanif W. Aslam Farooq |
| author_facet | Seemab Iqbal Muhammad Fakhar-e-Alam M. Atif N. Amin K.S. Alimgeer Adnan Ali Aqrab-ul-Ahmad Atif Hanif W. Aslam Farooq |
| author_sort | Seemab Iqbal |
| collection | DOAJ |
| description | In present study, we assessed the antitumor and antibacterial response of Zn0.5Co0.5Fe2O4 nanoparticles (NPs) synthesized usingsol-gel method. The toxicological mechanism of current smart materials is considered to be valuable keeping in view its many promising applications. The structure, morphology, and magnetic behavior of theZnxCo(1-x)Fe2O4 nanoparticles NPs were assessed using X-ray diffraction and scanning electron microscopy. The cytotoxic and photo-cytotoxic responses of the magnetic NPs were examined in a hepatocellular HepG2 model in the dark and under an optimum laser fluence dose of 80 J/cm2 using a wavelength of 630 nm for a short exposure time. A percentage loss of 60% was observed in a 250 µg/mL NP solution according to the cell viability of the labeled HepG2 cell model. Empirical modeling analysis revealed the reflex duplicate response of the experimental results. Antibacterial studies were performed on different types of bacteria via in vitro optical density analysis. Presented vision with varying factors will be useful for biomedical applications of Zn0.5Co0.5Fe2O4 nanoparticles. Keywords: Spinel ferrite, PDT, HepG2 model, NRA, Reactive oxygen species (ROS), Drug delivery, Sol-gel method, Bioactivity, Cell viability |
| first_indexed | 2024-12-13T04:32:18Z |
| format | Article |
| id | doaj.art-fe1ab5d68b5542d1afbfff709a4473fa |
| institution | Directory Open Access Journal |
| issn | 2211-3797 |
| language | English |
| last_indexed | 2024-12-13T04:32:18Z |
| publishDate | 2019-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Physics |
| spelling | doaj.art-fe1ab5d68b5542d1afbfff709a4473fa2022-12-21T23:59:31ZengElsevierResults in Physics2211-37972019-12-0115Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticlesSeemab Iqbal0Muhammad Fakhar-e-Alam1M. Atif2N. Amin3K.S. Alimgeer4Adnan Ali5 Aqrab-ul-Ahmad6Atif Hanif7W. Aslam Farooq8Department of Physics, G.C. University, Faisalabad 38000, PakistanDepartment of Physics, G.C. University, Faisalabad 38000, Pakistan; Corresponding authors.Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia; Corresponding authors.Department of Physics, G.C. University, Faisalabad 38000, PakistanDepartment of Electrical Engineering, COMSATS Institute of Information Technology, Islamabad, PakistanDepartment of Physics, G.C. University, Faisalabad 38000, PakistanDepartment of Physics, G.C. University, Faisalabad 38000, PakistanBotany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi ArabiaIn present study, we assessed the antitumor and antibacterial response of Zn0.5Co0.5Fe2O4 nanoparticles (NPs) synthesized usingsol-gel method. The toxicological mechanism of current smart materials is considered to be valuable keeping in view its many promising applications. The structure, morphology, and magnetic behavior of theZnxCo(1-x)Fe2O4 nanoparticles NPs were assessed using X-ray diffraction and scanning electron microscopy. The cytotoxic and photo-cytotoxic responses of the magnetic NPs were examined in a hepatocellular HepG2 model in the dark and under an optimum laser fluence dose of 80 J/cm2 using a wavelength of 630 nm for a short exposure time. A percentage loss of 60% was observed in a 250 µg/mL NP solution according to the cell viability of the labeled HepG2 cell model. Empirical modeling analysis revealed the reflex duplicate response of the experimental results. Antibacterial studies were performed on different types of bacteria via in vitro optical density analysis. Presented vision with varying factors will be useful for biomedical applications of Zn0.5Co0.5Fe2O4 nanoparticles. Keywords: Spinel ferrite, PDT, HepG2 model, NRA, Reactive oxygen species (ROS), Drug delivery, Sol-gel method, Bioactivity, Cell viabilityhttp://www.sciencedirect.com/science/article/pii/S2211379719314664 |
| spellingShingle | Seemab Iqbal Muhammad Fakhar-e-Alam M. Atif N. Amin K.S. Alimgeer Adnan Ali Aqrab-ul-Ahmad Atif Hanif W. Aslam Farooq Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles Results in Physics |
| title | Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles |
| title_full | Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles |
| title_fullStr | Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles |
| title_full_unstemmed | Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles |
| title_short | Structural, morphological, antimicrobial, and in vitro photodynamic therapeutic assessments of novel Zn+2-substituted cobalt ferrite nanoparticles |
| title_sort | structural morphological antimicrobial and in vitro photodynamic therapeutic assessments of novel zn 2 substituted cobalt ferrite nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2211379719314664 |
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