Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1
Aflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, and it is included in group I of human carcinogens. The European Commission has established maximum limits of AFB1 in feed, ranging from 5 to 20 μg/kg. Chicken is moderately sensitive to AFB1, which results in reduced grow...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.822227/full |
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| author | Sara Damiano Watanya Jarriyawattanachaikul Flavia Girolami Consiglia Longobardi Carlo Nebbia Emanuela Andretta Chiara Lauritano Sihem Dabbou Giuseppina Avantaggiato Achille Schiavone Paola Badino Roberto Ciarcia |
| author_facet | Sara Damiano Watanya Jarriyawattanachaikul Flavia Girolami Consiglia Longobardi Carlo Nebbia Emanuela Andretta Chiara Lauritano Sihem Dabbou Giuseppina Avantaggiato Achille Schiavone Paola Badino Roberto Ciarcia |
| author_sort | Sara Damiano |
| collection | DOAJ |
| description | Aflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, and it is included in group I of human carcinogens. The European Commission has established maximum limits of AFB1 in feed, ranging from 5 to 20 μg/kg. Chicken is moderately sensitive to AFB1, which results in reduced growth performance and economic losses. Oxidative stress triggered by AFB1 plays a crucial role in kidney damage and the antioxidant activity of Curcumin (CURC) could help in preventing such adverse effect. Twenty-days-old broilers were treated for 10 days with AFB1 (0.02 mg/kg feed), alone or in combination with CURC (400 mg/kg feed), to explore the effects on the renal tissue. Animals exposed to AFB1 alone displayed alterations of the oxidative stress parameters compared with controls: serum antioxidant capacity, and enzymatic activity of kidney superoxide dismutase, catalase and glutathione peroxidase were decreased, while renal malondialdehyde levels and NADPH oxidase complex expression were increased. The administration of CURC attenuates all the oxidative stress parameters modified by AFB1 in the chicken kidney, opening new perspectives in the management of aflatoxicosis. |
| first_indexed | 2024-12-20T16:11:50Z |
| format | Article |
| id | doaj.art-fe1c07eee02844df8134a00c3c54b96a |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-20T16:11:50Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-fe1c07eee02844df8134a00c3c54b96a2022-12-21T19:33:58ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-01-01810.3389/fvets.2021.822227822227Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1Sara Damiano0Watanya Jarriyawattanachaikul1Flavia Girolami2Consiglia Longobardi3Carlo Nebbia4Emanuela Andretta5Chiara Lauritano6Sihem Dabbou7Giuseppina Avantaggiato8Achille Schiavone9Paola Badino10Roberto Ciarcia11Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, ItalyDepartment of Veterinary Sciences, University of Torino, Grugliasco, ItalyDepartment of Veterinary Sciences, University of Torino, Grugliasco, ItalyDepartment of Mental, Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, ItalyDepartment of Veterinary Sciences, University of Torino, Grugliasco, ItalyDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, ItalyEcosustainable Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, Naples, ItalyCenter Agriculture Food Environment (C3A), University of Trento, San Michele all'Adige, ItalyInstitute of Sciences of Food Production, Italian National Research Council, Bari, ItalyDepartment of Veterinary Sciences, University of Torino, Grugliasco, ItalyDepartment of Veterinary Sciences, University of Torino, Grugliasco, ItalyDepartment of Veterinary Medicine and Animal Productions, University of Naples Federico II, Naples, ItalyAflatoxin B1 (AFB1) causes hepatotoxicity, immunotoxicity, and kidney damage, and it is included in group I of human carcinogens. The European Commission has established maximum limits of AFB1 in feed, ranging from 5 to 20 μg/kg. Chicken is moderately sensitive to AFB1, which results in reduced growth performance and economic losses. Oxidative stress triggered by AFB1 plays a crucial role in kidney damage and the antioxidant activity of Curcumin (CURC) could help in preventing such adverse effect. Twenty-days-old broilers were treated for 10 days with AFB1 (0.02 mg/kg feed), alone or in combination with CURC (400 mg/kg feed), to explore the effects on the renal tissue. Animals exposed to AFB1 alone displayed alterations of the oxidative stress parameters compared with controls: serum antioxidant capacity, and enzymatic activity of kidney superoxide dismutase, catalase and glutathione peroxidase were decreased, while renal malondialdehyde levels and NADPH oxidase complex expression were increased. The administration of CURC attenuates all the oxidative stress parameters modified by AFB1 in the chicken kidney, opening new perspectives in the management of aflatoxicosis.https://www.frontiersin.org/articles/10.3389/fvets.2021.822227/fullAflatoxin B1turmeric powdercurcuminoxidative stresskidneychicken—broiler |
| spellingShingle | Sara Damiano Watanya Jarriyawattanachaikul Flavia Girolami Consiglia Longobardi Carlo Nebbia Emanuela Andretta Chiara Lauritano Sihem Dabbou Giuseppina Avantaggiato Achille Schiavone Paola Badino Roberto Ciarcia Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 Frontiers in Veterinary Science Aflatoxin B1 turmeric powder curcumin oxidative stress kidney chicken—broiler |
| title | Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 |
| title_full | Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 |
| title_fullStr | Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 |
| title_full_unstemmed | Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 |
| title_short | Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1 |
| title_sort | curcumin supplementation protects broiler chickens against the renal oxidative stress induced by the dietary exposure to low levels of aflatoxin b1 |
| topic | Aflatoxin B1 turmeric powder curcumin oxidative stress kidney chicken—broiler |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.822227/full |
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