Changes of corneal nerve fibers in patients with Sjögren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops
AIM: To observe the nerve morphological changes in cornea of fluorometholone eye drops combined with sodium hyaluronate eye drops in the treatment of dry eye of Sjögren's syndrome by in vivo confocal microscopy(IVCM).METHODS: From January 2017 to July 2020, totally 52 dry eye patients(...
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Press of International Journal of Ophthalmology (IJO PRESS)
2021-11-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2021/11/202111032.pdf |
| _version_ | 1819030120380235776 |
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| author | Zhao Yang Feng-Mei Li Wen-Jing He Qi Chen |
| author_facet | Zhao Yang Feng-Mei Li Wen-Jing He Qi Chen |
| author_sort | Zhao Yang |
| collection | DOAJ |
| description | AIM: To observe the nerve morphological changes in cornea of fluorometholone eye drops combined with sodium hyaluronate eye drops in the treatment of dry eye of Sjögren's syndrome by in vivo confocal microscopy(IVCM).METHODS: From January 2017 to July 2020, totally 52 dry eye patients(104 eyes)of Sjögren's syndrome in our hospital were enrolled and were randomly divided into two groups: 26 patients(52 eyes)in the experimental group were treated with 0.1% fluorometholone eye drops and sodium hyaluronate eye drops, while 26 patients(52 eyes)in the control group were treated with sodium hyaluronate eye drops alone. The diameter of central corneal nerve fibers, the number of nerve beads, the score of nerve tortuosity, tear film break-up time(BUT), Schirmer I test(S I t)and non-contact intraocular pressure were measured before treatment and 2, 4 and 12wk after treatment.RESULTS: There were no significant differences in the results of the diameter of central corneal nerve fibers, the number of nerve beads, the score of nerve tortuosity, BUT, S I t and non-contact intraocular pressure between the two groups before treatment(P>0.05). At 2, 4 and 12wk after treatment, the BUT prolonged in the experimental group compared with the control group(P<0.05); At 12wk after treatment, the diameter of corneal nerve fibers increased, the number of nerve beads and the nerve tortuosity score decreased, the S I t increased in the experimental group compared with the control group(all P<0.05), and there were no significant difference in non-contact intraocular pressure(P>0.05).CONCLUSION: Fluorometholone eye drops combined with sodium hyaluronate eye drops is safe and effective in the treatment of Sjögren's syndrome related dry eye, and contribute to corneal nerve recovery. |
| first_indexed | 2024-12-21T06:25:06Z |
| format | Article |
| id | doaj.art-fe1ceacdf4f84a01a4aa6d4bf6be75f4 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-12-21T06:25:06Z |
| publishDate | 2021-11-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-fe1ceacdf4f84a01a4aa6d4bf6be75f42022-12-21T19:13:09ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232021-11-0121111992199610.3980/j.issn.1672-5123.2021.11.32202111032Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye dropsZhao Yang0Feng-Mei Li1Wen-Jing He2Qi Chen3Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaDepartment of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaDepartment of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaDepartment of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi Zhuang Autonomous Region, ChinaAIM: To observe the nerve morphological changes in cornea of fluorometholone eye drops combined with sodium hyaluronate eye drops in the treatment of dry eye of Sjögren's syndrome by in vivo confocal microscopy(IVCM).METHODS: From January 2017 to July 2020, totally 52 dry eye patients(104 eyes)of Sjögren's syndrome in our hospital were enrolled and were randomly divided into two groups: 26 patients(52 eyes)in the experimental group were treated with 0.1% fluorometholone eye drops and sodium hyaluronate eye drops, while 26 patients(52 eyes)in the control group were treated with sodium hyaluronate eye drops alone. The diameter of central corneal nerve fibers, the number of nerve beads, the score of nerve tortuosity, tear film break-up time(BUT), Schirmer I test(S I t)and non-contact intraocular pressure were measured before treatment and 2, 4 and 12wk after treatment.RESULTS: There were no significant differences in the results of the diameter of central corneal nerve fibers, the number of nerve beads, the score of nerve tortuosity, BUT, S I t and non-contact intraocular pressure between the two groups before treatment(P>0.05). At 2, 4 and 12wk after treatment, the BUT prolonged in the experimental group compared with the control group(P<0.05); At 12wk after treatment, the diameter of corneal nerve fibers increased, the number of nerve beads and the nerve tortuosity score decreased, the S I t increased in the experimental group compared with the control group(all P<0.05), and there were no significant difference in non-contact intraocular pressure(P>0.05).CONCLUSION: Fluorometholone eye drops combined with sodium hyaluronate eye drops is safe and effective in the treatment of Sjögren's syndrome related dry eye, and contribute to corneal nerve recovery.http://ies.ijo.cn/cn_publish/2021/11/202111032.pdffluorometholone sjogren's syndromedry eyenerve fiber |
| spellingShingle | Zhao Yang Feng-Mei Li Wen-Jing He Qi Chen Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops Guoji Yanke Zazhi fluorometholone sjogren's syndrome dry eye nerve fiber |
| title | Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops |
| title_full | Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops |
| title_fullStr | Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops |
| title_full_unstemmed | Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops |
| title_short | Changes of corneal nerve fibers in patients with Sj&#xF6;gren's syndrome treated with Fluorometholone combined with sodium hyaluronate eye drops |
| title_sort | changes of corneal nerve fibers in patients with sj x0026 xf6 gren s syndrome treated with fluorometholone combined with sodium hyaluronate eye drops |
| topic | fluorometholone sjogren's syndrome dry eye nerve fiber |
| url | http://ies.ijo.cn/cn_publish/2021/11/202111032.pdf |
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