Pericyte infection by HIV-1: a fatal attraction
Abstract While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Retrovirology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12977-022-00614-3 |
| _version_ | 1811188247224647680 |
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| author | Oandy Naranjo Silvia Torices Paul R. Clifford Manav T. Daftari Olivia M. Osborne Nikolai Fattakhov Michal Toborek |
| author_facet | Oandy Naranjo Silvia Torices Paul R. Clifford Manav T. Daftari Olivia M. Osborne Nikolai Fattakhov Michal Toborek |
| author_sort | Oandy Naranjo |
| collection | DOAJ |
| description | Abstract While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the vascular endothelium, including pericytes that envelope vascular endothelial cells. Pericytes are multifunctional cells that have been recognized for their essential role in angiogenesis, vessel maintenance, and blood flow rate. Most importantly, recent evidence has shown that pericytes can be a target of HIV-1 infection and support an active stage of the viral life cycle, with latency also suggested by in vitro data. Pericyte infection by HIV-1 has been confirmed in the postmortem human brains and in lungs from SIV-infected macaques. Moreover, pericyte dysfunction has been implicated in a variety of pathologies ranging from ischemic stroke to diabetes, which are common comorbidities among people with HIV-1. In this review, we discuss the role of pericytes during HIV-1 infection and their contribution to the progression of HIV-associated comorbidities. |
| first_indexed | 2024-04-11T14:16:20Z |
| format | Article |
| id | doaj.art-fe1d23929df24ad495c3baaceb18c726 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-11T14:16:20Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-fe1d23929df24ad495c3baaceb18c7262022-12-22T04:19:26ZengBMCRetrovirology1742-46902022-12-011911910.1186/s12977-022-00614-3Pericyte infection by HIV-1: a fatal attractionOandy Naranjo0Silvia Torices1Paul R. Clifford2Manav T. Daftari3Olivia M. Osborne4Nikolai Fattakhov5Michal Toborek6Department of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of MedicineAbstract While HIV-1 is primarily an infection of CD4 + T cells, there is an emerging interest towards understanding how infection of other cell types can contribute to HIV-associated comorbidities. For HIV-1 to cross from the blood stream into tissues, the virus must come in direct contact with the vascular endothelium, including pericytes that envelope vascular endothelial cells. Pericytes are multifunctional cells that have been recognized for their essential role in angiogenesis, vessel maintenance, and blood flow rate. Most importantly, recent evidence has shown that pericytes can be a target of HIV-1 infection and support an active stage of the viral life cycle, with latency also suggested by in vitro data. Pericyte infection by HIV-1 has been confirmed in the postmortem human brains and in lungs from SIV-infected macaques. Moreover, pericyte dysfunction has been implicated in a variety of pathologies ranging from ischemic stroke to diabetes, which are common comorbidities among people with HIV-1. In this review, we discuss the role of pericytes during HIV-1 infection and their contribution to the progression of HIV-associated comorbidities.https://doi.org/10.1186/s12977-022-00614-3PericytesHIV-1 comorbiditiesHIVBrain |
| spellingShingle | Oandy Naranjo Silvia Torices Paul R. Clifford Manav T. Daftari Olivia M. Osborne Nikolai Fattakhov Michal Toborek Pericyte infection by HIV-1: a fatal attraction Retrovirology Pericytes HIV-1 comorbidities HIV Brain |
| title | Pericyte infection by HIV-1: a fatal attraction |
| title_full | Pericyte infection by HIV-1: a fatal attraction |
| title_fullStr | Pericyte infection by HIV-1: a fatal attraction |
| title_full_unstemmed | Pericyte infection by HIV-1: a fatal attraction |
| title_short | Pericyte infection by HIV-1: a fatal attraction |
| title_sort | pericyte infection by hiv 1 a fatal attraction |
| topic | Pericytes HIV-1 comorbidities HIV Brain |
| url | https://doi.org/10.1186/s12977-022-00614-3 |
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