Old Drug, New Trick: Tilorone, a Broad-Spectrum Antiviral Drug as a Potential Anti-Fibrotic Therapeutic for the Diseased Heart

Old Drug, New Trick: Tilorone, a Broad-Spectrum Antiviral Drug as a Potential Anti-Fibrotic Therapeutic for the Diseased Heart

Cardiac fibrosis is associated with most forms of cardiovascular disease. No reliable therapies targeting cardiac fibrosis are available, thus identifying novel drugs that can resolve or prevent fibrosis is needed. Tilorone, an antiviral agent, can prevent fibrosis in a mouse model of lung disease....

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Bibliographic Details
Main Authors: Duncan Horlock, David M. Kaye, Catherine E. Winbanks, Xiao-Ming Gao, Helen Kiriazis, Daniel G. Donner, Paul Gregorevic, Julie R. McMullen, Bianca C. Bernardo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
heart failure
fibrosis
tilorone
pressure overload
fibroblast
treatment
Online Access:https://www.mdpi.com/1424-8247/14/3/263

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