An Overview on <i>Candida auris</i> in Healthcare Settings
<i>Candida auris</i> has become a major concern in critical care medicine due to the increasing number of immunocompromised patients and candidiasis is the most frequent cause of fungal infections. <i>C. auris</i> and other fungal pathogens are responsible for at least 13 mil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/9/913 |
| _version_ | 1827725739289477120 |
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| author | Maria Luisa Cristina Anna Maria Spagnolo Marina Sartini Alessio Carbone Martino Oliva Elisa Schinca Silvia Boni Emanuele Pontali |
| author_facet | Maria Luisa Cristina Anna Maria Spagnolo Marina Sartini Alessio Carbone Martino Oliva Elisa Schinca Silvia Boni Emanuele Pontali |
| author_sort | Maria Luisa Cristina |
| collection | DOAJ |
| description | <i>Candida auris</i> has become a major concern in critical care medicine due to the increasing number of immunocompromised patients and candidiasis is the most frequent cause of fungal infections. <i>C. auris</i> and other fungal pathogens are responsible for at least 13 million infections and 1.5 million deaths globally per year. In immunocompromised patients, infections can quickly become severe, causing wound infections, otitis and candidemia, resulting in high morbidity and mortality. The clinical presentation of <i>C. auris</i> is often non-specific and similar to other types of systemic infections; in addition, it is harder to identify from cultures than other, more common types of <i>Candida</i> spp. Some infections are particularly difficult to treat due to multi-resistance to several antifungal agents, including fluconazole (and other azoles), amphotericin B and echinocandins. This entails treatment with more drugs and at higher doses. Even after treatment for invasive infections, patients generally remain colonized for long periods, so all infection control measures must be followed during and after treatment of the <i>C. auris</i> infection. Screening patients for <i>C. auris</i> colonization enables facilities to identify individuals with <i>C. auris</i> colonization and to implement infection prevention and control measures. This pathogenic fungus shows an innate resilience, enabling survival and persistence in healthcare environment and the ability to rapidly colonize the patient’s skin and be easily transmitted within the healthcare setting, thus leading to a serious and prolonged outbreak. |
| first_indexed | 2024-03-10T22:35:44Z |
| format | Article |
| id | doaj.art-fe2161fa2cec4a62b2927f1765ea6018 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T22:35:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-fe2161fa2cec4a62b2927f1765ea60182023-11-19T11:29:02ZengMDPI AGJournal of Fungi2309-608X2023-09-019991310.3390/jof9090913An Overview on <i>Candida auris</i> in Healthcare SettingsMaria Luisa Cristina0Anna Maria Spagnolo1Marina Sartini2Alessio Carbone3Martino Oliva4Elisa Schinca5Silvia Boni6Emanuele Pontali7Department of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyDepartment of Health Sciences, University of Genoa, Via Pastore 1, 16132 Genoa, ItalyInfectious Disease Unit, Galliera Hospital, 16128 Genoa, ItalyInfectious Disease Unit, Galliera Hospital, 16128 Genoa, Italy<i>Candida auris</i> has become a major concern in critical care medicine due to the increasing number of immunocompromised patients and candidiasis is the most frequent cause of fungal infections. <i>C. auris</i> and other fungal pathogens are responsible for at least 13 million infections and 1.5 million deaths globally per year. In immunocompromised patients, infections can quickly become severe, causing wound infections, otitis and candidemia, resulting in high morbidity and mortality. The clinical presentation of <i>C. auris</i> is often non-specific and similar to other types of systemic infections; in addition, it is harder to identify from cultures than other, more common types of <i>Candida</i> spp. Some infections are particularly difficult to treat due to multi-resistance to several antifungal agents, including fluconazole (and other azoles), amphotericin B and echinocandins. This entails treatment with more drugs and at higher doses. Even after treatment for invasive infections, patients generally remain colonized for long periods, so all infection control measures must be followed during and after treatment of the <i>C. auris</i> infection. Screening patients for <i>C. auris</i> colonization enables facilities to identify individuals with <i>C. auris</i> colonization and to implement infection prevention and control measures. This pathogenic fungus shows an innate resilience, enabling survival and persistence in healthcare environment and the ability to rapidly colonize the patient’s skin and be easily transmitted within the healthcare setting, thus leading to a serious and prolonged outbreak.https://www.mdpi.com/2309-608X/9/9/913<i>Candida auris</i>healthcare infectionsantifungal resistanceepidemiologyprevention and control measures |
| spellingShingle | Maria Luisa Cristina Anna Maria Spagnolo Marina Sartini Alessio Carbone Martino Oliva Elisa Schinca Silvia Boni Emanuele Pontali An Overview on <i>Candida auris</i> in Healthcare Settings Journal of Fungi <i>Candida auris</i> healthcare infections antifungal resistance epidemiology prevention and control measures |
| title | An Overview on <i>Candida auris</i> in Healthcare Settings |
| title_full | An Overview on <i>Candida auris</i> in Healthcare Settings |
| title_fullStr | An Overview on <i>Candida auris</i> in Healthcare Settings |
| title_full_unstemmed | An Overview on <i>Candida auris</i> in Healthcare Settings |
| title_short | An Overview on <i>Candida auris</i> in Healthcare Settings |
| title_sort | overview on i candida auris i in healthcare settings |
| topic | <i>Candida auris</i> healthcare infections antifungal resistance epidemiology prevention and control measures |
| url | https://www.mdpi.com/2309-608X/9/9/913 |
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