Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma
Background and Purpose: Three-dimensional (3D) Magnetic Resonance Imaging (MRI) is increasingly used to complement conventional two-dimensional ultrasound in the assessment of tumour dimension measurement of uveal melanoma. However, the lack of definitions of the 3D measurements of these tumour dime...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Physics and Imaging in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631622000914 |
| _version_ | 1811196735084560384 |
|---|---|
| author | Lisa Klaassen Myriam G. Jaarsma-Coes Berit M. Verbist T.H. Khanh Vu Marina Marinkovic Coen R.N. Rasch Gregorius P.M. Luyten Jan-Willem M. Beenakker |
| author_facet | Lisa Klaassen Myriam G. Jaarsma-Coes Berit M. Verbist T.H. Khanh Vu Marina Marinkovic Coen R.N. Rasch Gregorius P.M. Luyten Jan-Willem M. Beenakker |
| author_sort | Lisa Klaassen |
| collection | DOAJ |
| description | Background and Purpose: Three-dimensional (3D) Magnetic Resonance Imaging (MRI) is increasingly used to complement conventional two-dimensional ultrasound in the assessment of tumour dimension measurement of uveal melanoma. However, the lack of definitions of the 3D measurements of these tumour dimensions hinders further adaptation of MRI in ocular radiotherapy planning. In this study, we composed 3D MR-based definitions of tumour prominence and basal diameter and compared them to conventional ultrasound. Materials and methods: Tumours were delineated on 3DT2 and contrast-enhanced 3DT1 (T1gd) MRI for 25 patients. 3D definitions of tumour prominence and diameter were composed and evaluated automatically on the T1gd and T2 contours. Automatic T1gd measurements were compared to manual MRI measurements, to automatic T2 measurements and to manual ultrasound measurements. Results: Prominence measurements were similar for all modalities (median absolute difference 0.3 mm). Automatic T1gd diameter measurements were generally larger than manual MRI, automatic T2 and manual ultrasound measurements (median absolute differences of 0.5, 1.6 and 1.1 mm respectively), mainly due to difficulty defining the axis of the largest diameter. Largest differences between ultrasound and MRI for both prominence and diameter were found in anteriorly located tumours (up to 1.6 and 4.5 mm respectively), for which the tumour extent could not entirely be visualized with ultrasound. Conclusions: The proposed 3D definitions for tumour prominence and diameter agreed well with ultrasound measurements for tumours for which the extent was visible on ultrasound. 3D MRI measurements generally provided larger diameter measurements than ultrasound. In anteriorly located tumours, the MRI measurements were considered more accurate than conventional ultrasound. |
| first_indexed | 2024-04-12T01:04:00Z |
| format | Article |
| id | doaj.art-fe23ab102b6c4431bd36db513e5f024c |
| institution | Directory Open Access Journal |
| issn | 2405-6316 |
| language | English |
| last_indexed | 2024-04-12T01:04:00Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj.art-fe23ab102b6c4431bd36db513e5f024c2022-12-22T03:54:21ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162022-10-0124102110Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanomaLisa Klaassen0Myriam G. Jaarsma-Coes1Berit M. Verbist2T.H. Khanh Vu3Marina Marinkovic4Coen R.N. Rasch5Gregorius P.M. Luyten6Jan-Willem M. Beenakker7Leiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the Netherlands; Leiden University Medical Center, Department of Radiology, PO Box 9600, 2300 RC Leiden, the Netherlands; Leiden University Medical Center, Department of Radiation Oncology, PO Box 9600, 2300 RC Leiden, the Netherlands; Corresponding author at: Postal Zone J3-S, PO Box 9600, 2300 RC Leiden, the Netherlands.Leiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the Netherlands; Leiden University Medical Center, Department of Radiology, PO Box 9600, 2300 RC Leiden, the NetherlandsLeiden University Medical Center, Department of Radiology, PO Box 9600, 2300 RC Leiden, the Netherlands; Holland Particle Therapy Center, PO Box 110, 2600 AC Delft, the NetherlandsLeiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the NetherlandsLeiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the NetherlandsLeiden University Medical Center, Department of Radiation Oncology, PO Box 9600, 2300 RC Leiden, the Netherlands; Holland Particle Therapy Center, PO Box 110, 2600 AC Delft, the NetherlandsLeiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the NetherlandsLeiden University Medical Center, Department of Ophthalmology, PO Box 9600, 2300 RC Leiden, the Netherlands; Leiden University Medical Center, Department of Radiology, PO Box 9600, 2300 RC Leiden, the Netherlands; Leiden University Medical Center, Department of Radiation Oncology, PO Box 9600, 2300 RC Leiden, the NetherlandsBackground and Purpose: Three-dimensional (3D) Magnetic Resonance Imaging (MRI) is increasingly used to complement conventional two-dimensional ultrasound in the assessment of tumour dimension measurement of uveal melanoma. However, the lack of definitions of the 3D measurements of these tumour dimensions hinders further adaptation of MRI in ocular radiotherapy planning. In this study, we composed 3D MR-based definitions of tumour prominence and basal diameter and compared them to conventional ultrasound. Materials and methods: Tumours were delineated on 3DT2 and contrast-enhanced 3DT1 (T1gd) MRI for 25 patients. 3D definitions of tumour prominence and diameter were composed and evaluated automatically on the T1gd and T2 contours. Automatic T1gd measurements were compared to manual MRI measurements, to automatic T2 measurements and to manual ultrasound measurements. Results: Prominence measurements were similar for all modalities (median absolute difference 0.3 mm). Automatic T1gd diameter measurements were generally larger than manual MRI, automatic T2 and manual ultrasound measurements (median absolute differences of 0.5, 1.6 and 1.1 mm respectively), mainly due to difficulty defining the axis of the largest diameter. Largest differences between ultrasound and MRI for both prominence and diameter were found in anteriorly located tumours (up to 1.6 and 4.5 mm respectively), for which the tumour extent could not entirely be visualized with ultrasound. Conclusions: The proposed 3D definitions for tumour prominence and diameter agreed well with ultrasound measurements for tumours for which the extent was visible on ultrasound. 3D MRI measurements generally provided larger diameter measurements than ultrasound. In anteriorly located tumours, the MRI measurements were considered more accurate than conventional ultrasound.http://www.sciencedirect.com/science/article/pii/S2405631622000914Uveal melanomaOcular oncologyMagnetic resonance imagingUltrasound |
| spellingShingle | Lisa Klaassen Myriam G. Jaarsma-Coes Berit M. Verbist T.H. Khanh Vu Marina Marinkovic Coen R.N. Rasch Gregorius P.M. Luyten Jan-Willem M. Beenakker Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma Physics and Imaging in Radiation Oncology Uveal melanoma Ocular oncology Magnetic resonance imaging Ultrasound |
| title | Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| title_full | Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| title_fullStr | Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| title_full_unstemmed | Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| title_short | Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| title_sort | automatic three dimensional magnetic resonance based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma |
| topic | Uveal melanoma Ocular oncology Magnetic resonance imaging Ultrasound |
| url | http://www.sciencedirect.com/science/article/pii/S2405631622000914 |
| work_keys_str_mv | AT lisaklaassen automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT myriamgjaarsmacoes automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT beritmverbist automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT thkhanhvu automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT marinamarinkovic automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT coenrnrasch automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT gregoriuspmluyten automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma AT janwillemmbeenakker automaticthreedimensionalmagneticresonancebasedmeasurementsoftumourprominenceandbasaldiameterfortreatmentplanningofuvealmelanoma |