Are Genetic Modifiers the Answer to Different Responses to Hydroxyurea Treatment?—A Pharmacogenetic Study in Sickle Cell Anemia Angolan Children

Are Genetic Modifiers the Answer to Different Responses to Hydroxyurea Treatment?—A Pharmacogenetic Study in Sickle Cell Anemia Angolan Children

Sickle cell anemia (SCA) is an inherited disease affecting the hemoglobin that is particularly common in sub-Saharan Africa. Although monogenic, phenotypes are markedly heterogeneous in terms of severity and life span. Hydroxyurea is still the most common treatment for these patients, and the respon...

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Bibliographic Details
Main Authors: Catarina Ginete, Mariana Delgadinho, Brígida Santos, Vera Pinto, Carina Silva, Armandina Miranda, Miguel Brito
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
sickle cell anemia
hydroxyurea
pharmacogenetics
next-generation sequencing (NGS)
Online Access:https://www.mdpi.com/1422-0067/24/10/8792

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