Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

Perindopril/Ambrosin Combination Mitigates Dextran Sulfate Sodium-Induced Colitis in Mice: Crosstalk between Toll-Like Receptor 4, the Pro-Inflammatory Pathways, and SIRT1/PPAR-γ Signaling

Colitis is one of the inflammatory states that affect the intestinal wall and may even predispose to malignancy due to chronic irritation. Although the etiology of colitis is not yet fully explored, a combination of genetic and environmental factors is strongly incriminated. Perindopril is an angiot...

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Bibliographic Details
Main Authors: Ahmed M. Kabel, Aliaa Atef, Hany M. Borg, Azza A. K. El-Sheikh, Hana J. Al Khabbaz, Hany H. Arab, Remon S. Estfanous
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceuticals
Subjects:
perindopril
ambrosin
dextran sulfate sodium
inflammation
colitis
mice
Online Access:https://www.mdpi.com/1424-8247/15/5/600

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