A Convenient Synthesis of (16<i>S</i>,20<i>S</i>)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its <i>N</i>-alkyl Derivatives

A Convenient Synthesis of (16<i>S</i>,20<i>S</i>)-3β-Hydroxy-5α-pregnane-20,16-carbolactam and Its <i>N</i>-alkyl Derivatives

A concise synthesis of (16<i>S</i>,20<i>S</i>)-3β-hydroxy-5α-pregnane-20,16-carbolactam from tigogenin via the corresponding lactone is described. The most efficient synthetic route consisted of the lactone ring-opening with aminoalane reagent followed by PDC or Dess-Martin o...

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Bibliographic Details
Main Authors: Agnieszka Wojtkielewicz, Damian Pawelski, Przemysław Bazydło, Aneta Baj, Stanisław Witkowski, Jacek W. Morzycki
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
lactams
reductive amination
spirostane degradation
steroids
Online Access:https://www.mdpi.com/1420-3049/25/10/2377

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